PEG/clay nanocomposite hydrogel: A mechanically robust tissue engineering scaffold

Published

Journal Article

Nanocomposite hydrogels with enhanced mechanical properties could have tremendous biomedical applications. Here we describe synthesis and characterizations of biocompatible poly(ethylene glycol) diacrylate (PEGDA)/Laponite nanocomposite (NC) hydrogels that can support both two- and three-dimensional (2D and 3D) cell cultures. The PEGDA/Laponite NC hydrogels with enhanced mechanical properties were developed by harnessing the ability of PEGDA oligomers to simultaneously form chemically crosslinked networks while interacting with Laponite nanoparticles through secondary interactions. Incorporation of Laponite nanoparticles significantly enhanced both the compressive and tensile properties of PEGDA hydrogels, which were dependent on both the molecular weight of PEG, and concentrations of Laponite nanoparticles. Unlike PEGDA hydrogels, PEGDA-NC hydrogels supported cell adhesion and their subsequent spreading in a 2D culture. In addition to supporting the 2D cell growth, the PEGDA NC hydrogels supported 3D cell encapsulation similar to that of widely used PEGDA hydrogel systems. Such nanocomposite hydrogels with enhanced mechanical properties could have potential applications as 3D scaffolds for tissue engineering. Additionally, the ability of PEGDA NC hydrogels to support 3D culture of encapsulated cells makes them an ideal injectable system with minimally invasive strategies for in vivo applications. © 2010 The Royal Society of Chemistry.

Full Text

Duke Authors

Cited Authors

  • Chang, CW; Van Spreeuwel, A; Zhang, C; Varghese, S

Published Date

  • October 21, 2010

Published In

Volume / Issue

  • 6 / 20

Start / End Page

  • 5157 - 5164

Electronic International Standard Serial Number (EISSN)

  • 1744-6848

International Standard Serial Number (ISSN)

  • 1744-683X

Digital Object Identifier (DOI)

  • 10.1039/c0sm00067a

Citation Source

  • Scopus