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PEG/clay nanocomposite hydrogel: A mechanically robust tissue engineering scaffold

Publication ,  Journal Article
Chang, CW; Van Spreeuwel, A; Zhang, C; Varghese, S
Published in: Soft Matter
October 21, 2010

Nanocomposite hydrogels with enhanced mechanical properties could have tremendous biomedical applications. Here we describe synthesis and characterizations of biocompatible poly(ethylene glycol) diacrylate (PEGDA)/Laponite nanocomposite (NC) hydrogels that can support both two- and three-dimensional (2D and 3D) cell cultures. The PEGDA/Laponite NC hydrogels with enhanced mechanical properties were developed by harnessing the ability of PEGDA oligomers to simultaneously form chemically crosslinked networks while interacting with Laponite nanoparticles through secondary interactions. Incorporation of Laponite nanoparticles significantly enhanced both the compressive and tensile properties of PEGDA hydrogels, which were dependent on both the molecular weight of PEG, and concentrations of Laponite nanoparticles. Unlike PEGDA hydrogels, PEGDA-NC hydrogels supported cell adhesion and their subsequent spreading in a 2D culture. In addition to supporting the 2D cell growth, the PEGDA NC hydrogels supported 3D cell encapsulation similar to that of widely used PEGDA hydrogel systems. Such nanocomposite hydrogels with enhanced mechanical properties could have potential applications as 3D scaffolds for tissue engineering. Additionally, the ability of PEGDA NC hydrogels to support 3D culture of encapsulated cells makes them an ideal injectable system with minimally invasive strategies for in vivo applications. © 2010 The Royal Society of Chemistry.

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Published In

Soft Matter

DOI

EISSN

1744-6848

ISSN

1744-683X

Publication Date

October 21, 2010

Volume

6

Issue

20

Start / End Page

5157 / 5164

Related Subject Headings

  • Chemical Physics
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences
 

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Chang, C. W., Van Spreeuwel, A., Zhang, C., & Varghese, S. (2010). PEG/clay nanocomposite hydrogel: A mechanically robust tissue engineering scaffold. Soft Matter, 6(20), 5157–5164. https://doi.org/10.1039/c0sm00067a
Chang, C. W., A. Van Spreeuwel, C. Zhang, and S. Varghese. “PEG/clay nanocomposite hydrogel: A mechanically robust tissue engineering scaffold.” Soft Matter 6, no. 20 (October 21, 2010): 5157–64. https://doi.org/10.1039/c0sm00067a.
Chang CW, Van Spreeuwel A, Zhang C, Varghese S. PEG/clay nanocomposite hydrogel: A mechanically robust tissue engineering scaffold. Soft Matter. 2010 Oct 21;6(20):5157–64.
Chang, C. W., et al. “PEG/clay nanocomposite hydrogel: A mechanically robust tissue engineering scaffold.” Soft Matter, vol. 6, no. 20, Oct. 2010, pp. 5157–64. Scopus, doi:10.1039/c0sm00067a.
Chang CW, Van Spreeuwel A, Zhang C, Varghese S. PEG/clay nanocomposite hydrogel: A mechanically robust tissue engineering scaffold. Soft Matter. 2010 Oct 21;6(20):5157–5164.
Journal cover image

Published In

Soft Matter

DOI

EISSN

1744-6848

ISSN

1744-683X

Publication Date

October 21, 2010

Volume

6

Issue

20

Start / End Page

5157 / 5164

Related Subject Headings

  • Chemical Physics
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences