Association between pain, radiographic severity, and centrally-mediated symptoms in women with knee osteoarthritis.


Journal Article

To examine the relationship between pain, radiographic severity, and a common set of co-occurring centrally-mediated symptoms (fatigue, sleep quality, and depression) in women with knee osteoarthritis.Participants underwent knee radiographs, and had repeated assessments of pain severity and other centrally-mediated symptoms during a 5-day home monitoring period. To examine associations between pain severity (the average of pain over the home monitoring period), measures of osteoarthritis radiographic severity (Kellgren/Lawrence grade, minimum joint space width), centrally-mediated symptoms, and demographics (age) were used. Symptoms of fatigue, sleep efficiency, and depression were used in a composite measure representing centrally-mediated symptoms.Using a series of linear regression models in which each variable was entered hierarchically (n = 54), the final model showed that 27% of the variance in pain severity was explained by age, radiographic severity, and centrally-mediated symptoms. Centrally-mediated symptoms explained an additional 10% of the variance in pain severity after the other 2 variables were entered.Both radiographic severity and centrally-mediated symptoms were independently and significantly associated with pain severity in women with knee osteoarthritis. In addition to more severe radiographic features, women with higher centrally-mediated symptoms had greater pain severity. Treatments for women with symptomatic knee osteoarthritis may be optimized by addressing both peripheral and central sources of pain.

Full Text

Cited Authors

  • Murphy, SL; Lyden, AK; Phillips, K; Clauw, DJ; Williams, DA

Published Date

  • November 2011

Published In

Volume / Issue

  • 63 / 11

Start / End Page

  • 1543 - 1549

PubMed ID

  • 22034116

Pubmed Central ID

  • 22034116

Electronic International Standard Serial Number (EISSN)

  • 2151-4658

International Standard Serial Number (ISSN)

  • 2151-464X

Digital Object Identifier (DOI)

  • 10.1002/acr.20583


  • eng