Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism.

Published

Journal Article

BACKGROUND: Somatic symptoms are common in conditions such as fibromyalgia (FM) and chronic fatigue syndrome (CFS). OBJECTIVE: Authors investigated a potential shared pathologic mechanism: a generalized perceptual abnormality where there is heightened responsiveness to varied sensory stimulation, including pain. METHOD: A composite measure of sensory sensitivity was created and compared with measures of somatic symptoms, comorbid psychological disturbances, and self-reported physical functioning in 38 patients with FM and/or CFS. RESULTS: Sensory amplification influenced physical functioning indirectly through pain intensity, and physical symptoms and fatigue also independently contributed to physical functioning. CONCLUSION: Sensory amplification may be an underlying pathophysiologic mechanism in these disorders that is relatively independent of depression and depressive symptoms.

Full Text

Cited Authors

  • Geisser, ME; Strader Donnell, C; Petzke, F; Gracely, RH; Clauw, DJ; Williams, DA

Published Date

  • May 2008

Published In

Volume / Issue

  • 49 / 3

Start / End Page

  • 235 - 242

PubMed ID

  • 18448779

Pubmed Central ID

  • 18448779

Electronic International Standard Serial Number (EISSN)

  • 1545-7206

International Standard Serial Number (ISSN)

  • 0033-3182

Digital Object Identifier (DOI)

  • 10.1176/appi.psy.49.3.235

Language

  • eng