Radiative engineering of nanoantenna arrays for ultra-sensitive vibrational spectroscopy of proteins

Published

Conference Paper

Infrared absorption spectroscopy offers direct access to the vibrational signatures of molecular structure. Although absorption cross sections are nearly 10 orders of magnitude larger than the Raman cross sections, they are small in comparison with those of fluorescent labels. Sensitivity improvements are therefore required in order for the method to be applicable to single molecule/monolayer studies. In this work, we demonstrate a plasmon enhanced vibrational spectroscopy technique which allow for the measurement of molecule specific signatures at the monolayer level. Specifically, we show 4-5 order of magnitude enhancement of the amide-I and II backbone signature of protein monolayers, the signal resulting from only zeptomole quantities of molecules. © 2010 SPIE.

Full Text

Duke Authors

Cited Authors

  • Adato, R; Yanik, AA; Amsden, JJ; Kaplan, DL; Omenetto, FG; Hong, MK; Erramilli, S; Altug, H

Published Date

  • December 1, 2010

Published In

Volume / Issue

  • 7757 /

International Standard Serial Number (ISSN)

  • 0277-786X

International Standard Book Number 13 (ISBN-13)

  • 9780819482532

Digital Object Identifier (DOI)

  • 10.1117/12.861031

Citation Source

  • Scopus