Bioactive "self-sensing" optical systems

Journal Article (Journal Article)

Free-standing silk films are useful materials to manufacture nanopatterned optical elements and to immobilize bio-dopants such as enzymes while maintaining their biological activity. These traits were combined by incorporating hemoglobin into free-standing silk diffraction gratings to fabricate chemically responsive optofluidic devices responsive to ambient gas conditions, constituting a simple oxygen sensor. This type of self-analyzing optical system is enabled by the unique ability to reproduce high-fidelity optical structures in silk while maintaining the activity of entrapped proteins such as hemoglobin. These bioactive optical devices offer a direct readout capability, adding utility into the bioresponsive material arena. © 2009 American Institute of Physics.

Full Text

Duke Authors

Cited Authors

  • Domachuk, P; Perry, H; Amsden, JJ; Kaplan, DL; Omenetto, FG

Published Date

  • December 1, 2009

Published In

Volume / Issue

  • 95 / 25

International Standard Serial Number (ISSN)

  • 0003-6951

Digital Object Identifier (DOI)

  • 10.1063/1.3275719

Citation Source

  • Scopus