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Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses.

Publication ,  Journal Article
Huang, YZ; Won, S; Ali, DW; Wang, Q; Tanowitz, M; Du, QS; Pelkey, KA; Yang, DJ; Xiong, WC; Salter, MW; Mei, L
Published in: Neuron
May 2000

Neuregulins (NRGs) and their receptors, the ErbB protein tyrosine kinases, are essential for neuronal development, but their functions in the adult CNS are unknown. We report that ErbB4 is enriched in the postsynaptic density (PSD) and associates with PSD-95. Heterologous expression of PSD-95 enhanced NRG activation of ErbB4 and MAP kinase. Conversely, inhibiting expression of PSD-95 in neurons attenuated NRG-mediated activation of MAP kinase. PSD-95 formed a ternary complex with two molecules of ErbB4, suggesting that PSD-95 facilitates ErbB4 dimerization. Finally, NRG suppressed induction of long-term potentiation in the hippocampal CA1 region without affecting basal synaptic transmission. Thus, NRG signaling may be synaptic and regulated by PSD-95. A role of NRG signaling in the adult CNS may be modulation of synaptic plasticity.

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Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

May 2000

Volume

26

Issue

2

Start / End Page

443 / 455

Location

United States

Related Subject Headings

  • Yeasts
  • Tissue Distribution
  • Synapses
  • Signal Transduction
  • Receptor, ErbB-4
  • Rats
  • Neurons
  • Neurology & Neurosurgery
  • Neuregulins
  • Nerve Tissue Proteins
 

Citation

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Huang, Y. Z., Won, S., Ali, D. W., Wang, Q., Tanowitz, M., Du, Q. S., … Mei, L. (2000). Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron, 26(2), 443–455. https://doi.org/10.1016/s0896-6273(00)81176-9
Huang, Y. Z., S. Won, D. W. Ali, Q. Wang, M. Tanowitz, Q. S. Du, K. A. Pelkey, et al. “Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses.Neuron 26, no. 2 (May 2000): 443–55. https://doi.org/10.1016/s0896-6273(00)81176-9.
Huang YZ, Won S, Ali DW, Wang Q, Tanowitz M, Du QS, et al. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron. 2000 May;26(2):443–55.
Huang, Y. Z., et al. “Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses.Neuron, vol. 26, no. 2, May 2000, pp. 443–55. Pubmed, doi:10.1016/s0896-6273(00)81176-9.
Huang YZ, Won S, Ali DW, Wang Q, Tanowitz M, Du QS, Pelkey KA, Yang DJ, Xiong WC, Salter MW, Mei L. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron. 2000 May;26(2):443–455.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

May 2000

Volume

26

Issue

2

Start / End Page

443 / 455

Location

United States

Related Subject Headings

  • Yeasts
  • Tissue Distribution
  • Synapses
  • Signal Transduction
  • Receptor, ErbB-4
  • Rats
  • Neurons
  • Neurology & Neurosurgery
  • Neuregulins
  • Nerve Tissue Proteins