A study of the repetitive structure and distribution of short motifs in human genomic sequences.

Published

Journal Article

Over the last several years the search for functional genomic elements by exploiting motif over-representation became increasingly popular. However, about half of the human genome is repetitive, and that is also the case with most higher eukaryotes. In this study we have shown that in addition to these known repeats, human sequences feature many short over-represented motifs, and that their frequency varies only slightly between random repeat-masked sequences and regions located immediately upstream of the known genes. Most of our study has been performed on the ENCODE sequences, which comprise about 1% of the human genome.

Full Text

Duke Authors

Cited Authors

  • Singh, A; Feschotte, C; Stojanovic, N

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 3 / 4

Start / End Page

  • 523 - 535

PubMed ID

  • 18048317

Pubmed Central ID

  • 18048317

Electronic International Standard Serial Number (EISSN)

  • 1744-5493

International Standard Serial Number (ISSN)

  • 1744-5485

Digital Object Identifier (DOI)

  • 10.1504/ijbra.2007.015419

Language

  • eng