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Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting.

Publication ,  Journal Article
Grecu, L; Bittner, EA; Kher, J; Smith, SE; Rosow, CE
Published in: Anesth Analg
May 2008

INTRODUCTION: Haloperidol 1 mg and ondansetron 4 mg are equally safe and effective for postoperative nausea and vomiting prophylaxis. We compared the combination to ondansetron alone in a mixed surgical population. METHODS: Two-hundred and sixty-eight adults undergoing general anesthesia received 4 mg ondansetron plus 1 mg haloperidol or saline in this randomized, double-blind protocol. Efficacy and safety data were obtained until 480 min after postanesthesia care unit entry. RESULTS: The combination had more complete responders (76.2% vs 59.2%), less nausea, less rescue, and longer time to rescue. Sedation, time to postanesthesia care unit discharge, and QTc prolongation were not different. No subject had dystonia, akathisia, or serious dysrhythmias. CONCLUSIONS: Postoperative nausea and vomiting prophylaxis with both drugs is significantly more effective and longer lasting than ondansetron alone. There is no detectable increase in side effects.

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Published In

Anesth Analg

DOI

EISSN

1526-7598

Publication Date

May 2008

Volume

106

Issue

5

Start / End Page

1410 / 1413

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Postoperative Nausea and Vomiting
  • Ondansetron
  • Middle Aged
  • Male
  • Humans
  • Haloperidol
  • Female
  • Elective Surgical Procedures
 

Citation

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Grecu, L., Bittner, E. A., Kher, J., Smith, S. E., & Rosow, C. E. (2008). Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting. Anesth Analg, 106(5), 1410–1413. https://doi.org/10.1213/ane.0b013e31816091f0
Grecu, Loreta, Edward A. Bittner, Jay Kher, Sarah E. Smith, and Carl E. Rosow. “Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting.Anesth Analg 106, no. 5 (May 2008): 1410–13. https://doi.org/10.1213/ane.0b013e31816091f0.
Grecu L, Bittner EA, Kher J, Smith SE, Rosow CE. Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008 May;106(5):1410–3.
Grecu, Loreta, et al. “Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting.Anesth Analg, vol. 106, no. 5, May 2008, pp. 1410–13. Pubmed, doi:10.1213/ane.0b013e31816091f0.
Grecu L, Bittner EA, Kher J, Smith SE, Rosow CE. Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008 May;106(5):1410–1413.

Published In

Anesth Analg

DOI

EISSN

1526-7598

Publication Date

May 2008

Volume

106

Issue

5

Start / End Page

1410 / 1413

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Postoperative Nausea and Vomiting
  • Ondansetron
  • Middle Aged
  • Male
  • Humans
  • Haloperidol
  • Female
  • Elective Surgical Procedures