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Racial Differences of Pigmentation in the Human Vestibular Organs.

Publication ,  Conference
Erbele, ID; Lin, FR; Agrawal, Y; Francis, HW; Carey, JP; Chien, WW
Published in: Otolaryngol Head Neck Surg
September 2016

OBJECTIVES: Melanin pigmentation is present in the human inner ear. In this study, we quantify the melanin pigmentation in the vestibular system and examine racial differences of vestibular melanin pigmentation using human cadaveric temporal bone specimens. STUDY DESIGN: Basic research. SETTING: Laboratory. SUBJECTS AND METHODS: Light microscopy was used to examine specimens from 40 left temporal bones from the Johns Hopkins Human Temporal Bone Collection. Color images of (1) ampulla of the horizontal canal, (2) utricular wall, (3) endolymphatic duct, and (4) posterior ampullary nerve as it enters the posterior canal were acquired with a digital camera attached to the microscope and image acquisition software. Acquired images of each anatomic area of interest were processed offline through ImageJ. Melanin content was then compared according to ethnicity, age, sex, and location. RESULTS: Fifteen African American and 25 Caucasian specimens were analyzed. Mean age was 68.8 years. African American specimens had a significantly greater amount of pigment at all 4 sampled locations as compared with Caucasian specimens (P < .01). Between sexes, there was a statistically significant difference (P < .05) at the posterior ampullary nerve, with males having more than females. Melanin content was not associated with age. CONCLUSIONS: There is greater melanin pigmentation within the vestibular system of African Americans than in Caucasians, similar to what has been described in the cochlea. Racial differences in vestibular physiologic function have been observed in the literature and may be explained by differences in melanin pigmentation.

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Published In

Otolaryngol Head Neck Surg

DOI

EISSN

1097-6817

Publication Date

September 2016

Volume

155

Issue

3

Start / End Page

479 / 484

Location

England

Related Subject Headings

  • White People
  • Vestibule, Labyrinth
  • Temporal Bone
  • Software
  • Pigmentation
  • Otorhinolaryngology
  • Melanins
  • Male
  • Humans
  • Female
 

Citation

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Erbele, I. D., Lin, F. R., Agrawal, Y., Francis, H. W., Carey, J. P., & Chien, W. W. (2016). Racial Differences of Pigmentation in the Human Vestibular Organs. In Otolaryngol Head Neck Surg (Vol. 155, pp. 479–484). England. https://doi.org/10.1177/0194599816645764
Erbele, Isaac D., Frank R. Lin, Yuri Agrawal, Howard W. Francis, John P. Carey, and Wade W. Chien. “Racial Differences of Pigmentation in the Human Vestibular Organs.” In Otolaryngol Head Neck Surg, 155:479–84, 2016. https://doi.org/10.1177/0194599816645764.
Erbele ID, Lin FR, Agrawal Y, Francis HW, Carey JP, Chien WW. Racial Differences of Pigmentation in the Human Vestibular Organs. In: Otolaryngol Head Neck Surg. 2016. p. 479–84.
Erbele, Isaac D., et al. “Racial Differences of Pigmentation in the Human Vestibular Organs.Otolaryngol Head Neck Surg, vol. 155, no. 3, 2016, pp. 479–84. Pubmed, doi:10.1177/0194599816645764.
Erbele ID, Lin FR, Agrawal Y, Francis HW, Carey JP, Chien WW. Racial Differences of Pigmentation in the Human Vestibular Organs. Otolaryngol Head Neck Surg. 2016. p. 479–484.
Journal cover image

Published In

Otolaryngol Head Neck Surg

DOI

EISSN

1097-6817

Publication Date

September 2016

Volume

155

Issue

3

Start / End Page

479 / 484

Location

England

Related Subject Headings

  • White People
  • Vestibule, Labyrinth
  • Temporal Bone
  • Software
  • Pigmentation
  • Otorhinolaryngology
  • Melanins
  • Male
  • Humans
  • Female