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Risk Assessment and Prevention of Corneal Complications After Lateral Skull Base Surgery.

Publication ,  Journal Article
Sharon, JD; Kraus, CL; Ehrenburg, M; Weinreich, HM; Francis, HW
Published in: Otol Neurotol
September 2016

OBJECTIVE: To analyze the rate of corneal complications after lateral skull base surgery, and the relative risk of each potential contributing factor. STUDY DESIGN: Retrospective cohort study. SETTING: Tertiary care center. PATIENTS: Adult patients who had undergone lateral skull base surgery involving an otolaryngologist at our institution from 2007 to 2015. INTERVENTION: None. MAIN OUTCOME MEASURE: Relative risk (RR) for each potential contributing factor to corneal complications. RESULTS: Four hundred sixty nine patients met inclusion criteria. Of those, 35 developed mild exposure keratopathy, 13 developed moderate exposure keratopathy, and 5 developed severe exposure keratopathy. Age, sex, previous eye surgery, tumor side, and pathology were not significant predictors of keratopathy. Tumor size greater than 30 mm (RR 4.75), postoperative trigeminal palsy (RR 3.42), postoperative abducens palsy (RR 9.08), House-Brackman score 5-6 (RR 4.77), lagophthalmos (RR 11.85), ectropion (RR 4.29), and previous eye disease (RR 1.83) were all significantly associated with the development of corneal complications. On multivariate analysis, lagophthalmos, abducens palsy, and tumor size were independent predictors of keratopathy. CONCLUSIONS: There are several important risk factors for exposure keratopathy after lateral skull base surgery, and knowledge of these risk factors can help identify high-risk patients in whom early, aggressive preventative therapy is warranted.

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Published In

Otol Neurotol

DOI

EISSN

1537-4505

Publication Date

September 2016

Volume

37

Issue

8

Start / End Page

1148 / 1154

Location

United States

Related Subject Headings

  • Skull Base Neoplasms
  • Skull Base
  • Risk Factors
  • Retrospective Studies
  • Postoperative Complications
  • Otorhinolaryngology
  • Orthopedic Procedures
  • Neurosurgical Procedures
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
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Sharon, J. D., Kraus, C. L., Ehrenburg, M., Weinreich, H. M., & Francis, H. W. (2016). Risk Assessment and Prevention of Corneal Complications After Lateral Skull Base Surgery. Otol Neurotol, 37(8), 1148–1154. https://doi.org/10.1097/MAO.0000000000001123
Sharon, Jeffrey D., Courtney L. Kraus, Matthew Ehrenburg, Heather M. Weinreich, and Howard W. Francis. “Risk Assessment and Prevention of Corneal Complications After Lateral Skull Base Surgery.Otol Neurotol 37, no. 8 (September 2016): 1148–54. https://doi.org/10.1097/MAO.0000000000001123.
Sharon JD, Kraus CL, Ehrenburg M, Weinreich HM, Francis HW. Risk Assessment and Prevention of Corneal Complications After Lateral Skull Base Surgery. Otol Neurotol. 2016 Sep;37(8):1148–54.
Sharon, Jeffrey D., et al. “Risk Assessment and Prevention of Corneal Complications After Lateral Skull Base Surgery.Otol Neurotol, vol. 37, no. 8, Sept. 2016, pp. 1148–54. Pubmed, doi:10.1097/MAO.0000000000001123.
Sharon JD, Kraus CL, Ehrenburg M, Weinreich HM, Francis HW. Risk Assessment and Prevention of Corneal Complications After Lateral Skull Base Surgery. Otol Neurotol. 2016 Sep;37(8):1148–1154.

Published In

Otol Neurotol

DOI

EISSN

1537-4505

Publication Date

September 2016

Volume

37

Issue

8

Start / End Page

1148 / 1154

Location

United States

Related Subject Headings

  • Skull Base Neoplasms
  • Skull Base
  • Risk Factors
  • Retrospective Studies
  • Postoperative Complications
  • Otorhinolaryngology
  • Orthopedic Procedures
  • Neurosurgical Procedures
  • Middle Aged
  • Male