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Arachnoid granulations of the temporal bone: a histologic study of dural and osseous penetration.

Publication ,  Journal Article
Yew, M; Dubbs, B; Tong, O; Nager, GT; Niparko, JK; Tatlipinar, A; Francis, HW
Published in: Otol Neurotol
June 2011

HYPOTHESIS: Arachnoid granulations (AG) are more prevalent along the middle fossa surface of the temporal bone, where they produce larger bony defects than those occurring on the posterior surface. BACKGROUND: Dural and bony defects formed by AGs are proposed to lead to spontaneous meningoencephaloceles and cerebrospinal fluid otorrhea. They most commonly occur at the tegmen and in individuals older than 40 years. METHODS: Vertically sectioned temporal bones were evaluated using light microscopy to determine AG histology, distribution, and morphometry and to determine the prevalence of AG penetration in the donor population. RESULTS: AGs were observed to penetrate the dura mater and make direct contact with cortical surfaces in 12.7% of donors in the Johns Hopkins Temporal Bone Collection. AGs occurred at middle fossa sites 13% more frequently than at posterior fossa sites. At middle fossa sites AGs produced significantly larger bony openings and were more likely to be associated with herniating brain tissue. Donors with AGs were significantly older, and all were in the late 30s or older. CONCLUSION: Erosion of the temporal bone by AGs is not a rare occurrence in the population and becomes increasingly prevalent with age. It is estimated that 14 in 1,000 donors were at greatest risk of eventual cerebrospinal fluid leakage at the tegmen. The age and anatomic distribution described in this study strengthens the notion that AG penetration plays a role in the pathophysiology of spontaneous cerebrospinal fluid leaks and meningoencephaloceles of the temporal bone.

Duke Scholars

Published In

Otol Neurotol

DOI

EISSN

1537-4505

Publication Date

June 2011

Volume

32

Issue

4

Start / End Page

602 / 609

Location

United States

Related Subject Headings

  • Temporal Bone
  • Otorhinolaryngology
  • Middle Aged
  • Male
  • Humans
  • Female
  • Dura Mater
  • Cerebrospinal Fluid Otorrhea
  • Arachnoid
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yew, M., Dubbs, B., Tong, O., Nager, G. T., Niparko, J. K., Tatlipinar, A., & Francis, H. W. (2011). Arachnoid granulations of the temporal bone: a histologic study of dural and osseous penetration. Otol Neurotol, 32(4), 602–609. https://doi.org/10.1097/MAO.0b013e3182129026
Yew, Margaret, Basil Dubbs, Olivia Tong, George T. Nager, John K. Niparko, Arzu Tatlipinar, and Howard W. Francis. “Arachnoid granulations of the temporal bone: a histologic study of dural and osseous penetration.Otol Neurotol 32, no. 4 (June 2011): 602–9. https://doi.org/10.1097/MAO.0b013e3182129026.
Yew M, Dubbs B, Tong O, Nager GT, Niparko JK, Tatlipinar A, et al. Arachnoid granulations of the temporal bone: a histologic study of dural and osseous penetration. Otol Neurotol. 2011 Jun;32(4):602–9.
Yew, Margaret, et al. “Arachnoid granulations of the temporal bone: a histologic study of dural and osseous penetration.Otol Neurotol, vol. 32, no. 4, June 2011, pp. 602–09. Pubmed, doi:10.1097/MAO.0b013e3182129026.
Yew M, Dubbs B, Tong O, Nager GT, Niparko JK, Tatlipinar A, Francis HW. Arachnoid granulations of the temporal bone: a histologic study of dural and osseous penetration. Otol Neurotol. 2011 Jun;32(4):602–609.

Published In

Otol Neurotol

DOI

EISSN

1537-4505

Publication Date

June 2011

Volume

32

Issue

4

Start / End Page

602 / 609

Location

United States

Related Subject Headings

  • Temporal Bone
  • Otorhinolaryngology
  • Middle Aged
  • Male
  • Humans
  • Female
  • Dura Mater
  • Cerebrospinal Fluid Otorrhea
  • Arachnoid
  • Aged