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Reconciling conflicting models for global control of cell-cycle transcription.

Publication ,  Journal Article
Cho, C-Y; Motta, FC; Kelliher, CM; Deckard, A; Haase, SB
Published in: Cell cycle (Georgetown, Tex.)
October 2017

Models for the control of global cell-cycle transcription have advanced from a CDK-APC/C oscillator, a transcription factor (TF) network, to coupled CDK-APC/C and TF networks. Nonetheless, current models were challenged by a recent study that concluded that the cell-cycle transcriptional program is primarily controlled by a CDK-APC/C oscillator in budding yeast. Here we report an analysis of the transcriptome dynamics in cyclin mutant cells that were not queried in the previous study. We find that B-cyclin oscillation is not essential for control of phase-specific transcription. Using a mathematical model, we demonstrate that the function of network TFs can be retained in the face of significant reductions in transcript levels. Finally, we show that cells arrested at mitotic exit with non-oscillating levels of B-cyclins continue to cycle transcriptionally. Taken together, these findings support a critical role of a TF network and a requirement for CDK activities that need not be periodic.

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Published In

Cell cycle (Georgetown, Tex.)

DOI

EISSN

1551-4005

ISSN

1538-4101

Publication Date

October 2017

Volume

16

Issue

20

Start / End Page

1965 / 1978

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Saccharomyces cerevisiae
  • Periodicity
  • Models, Biological
  • Mitosis
  • Gene Regulatory Networks
  • Gene Expression Regulation
  • Developmental Biology
  • Cyclin B
 

Citation

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Cho, C.-Y., Motta, F. C., Kelliher, C. M., Deckard, A., & Haase, S. B. (2017). Reconciling conflicting models for global control of cell-cycle transcription. Cell Cycle (Georgetown, Tex.), 16(20), 1965–1978. https://doi.org/10.1080/15384101.2017.1367073
Cho, Chun-Yi, Francis C. Motta, Christina M. Kelliher, Anastasia Deckard, and Steven B. Haase. “Reconciling conflicting models for global control of cell-cycle transcription.Cell Cycle (Georgetown, Tex.) 16, no. 20 (October 2017): 1965–78. https://doi.org/10.1080/15384101.2017.1367073.
Cho C-Y, Motta FC, Kelliher CM, Deckard A, Haase SB. Reconciling conflicting models for global control of cell-cycle transcription. Cell cycle (Georgetown, Tex). 2017 Oct;16(20):1965–78.
Cho, Chun-Yi, et al. “Reconciling conflicting models for global control of cell-cycle transcription.Cell Cycle (Georgetown, Tex.), vol. 16, no. 20, Oct. 2017, pp. 1965–78. Epmc, doi:10.1080/15384101.2017.1367073.
Cho C-Y, Motta FC, Kelliher CM, Deckard A, Haase SB. Reconciling conflicting models for global control of cell-cycle transcription. Cell cycle (Georgetown, Tex). 2017 Oct;16(20):1965–1978.

Published In

Cell cycle (Georgetown, Tex.)

DOI

EISSN

1551-4005

ISSN

1538-4101

Publication Date

October 2017

Volume

16

Issue

20

Start / End Page

1965 / 1978

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Saccharomyces cerevisiae
  • Periodicity
  • Models, Biological
  • Mitosis
  • Gene Regulatory Networks
  • Gene Expression Regulation
  • Developmental Biology
  • Cyclin B