Retinal imaging in human autopsy eyes using a custom optical coherence tomography periscope.

Journal Article (Journal Article)

Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly. To better study the pathobiology of AMD, postmortem eyes offer an excellent opportunity to correlate optical coherence tomography (OCT) imaging characteristics with histopathology. However, postmortem eyes from autopsy present challenges to standard OCT imaging including opaque anterior segment structures and standard of care autopsy processing resulting in oblique views to the macula. To overcome these challenges, we report a custom periscope attached by a standard mount to an OCT sample arm and demonstrate high quality macular OCT acquisitions in autopsy-processed eyes.

Full Text

Duke Authors

Cited Authors

  • McNabb, RP; Tian, J; Farsiu, S; Izatt, JA; Lad, EM; Kuo, AN

Published Date

  • September 1, 2017

Published In

Volume / Issue

  • 8 / 9

Start / End Page

  • 4152 - 4159

PubMed ID

  • 28966854

Pubmed Central ID

  • PMC5611930

International Standard Serial Number (ISSN)

  • 2156-7085

Digital Object Identifier (DOI)

  • 10.1364/BOE.8.004152


  • eng

Conference Location

  • United States