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Genome Engineering for Personalized Arthritis Therapeutics.

Publication ,  Journal Article
Adkar, SS; Brunger, JM; Willard, VP; Wu, C-L; Gersbach, CA; Guilak, F
Published in: Trends in molecular medicine
October 2017

Arthritis represents a family of complex joint pathologies responsible for the majority of musculoskeletal conditions. Nearly all diseases within this family, including osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis, are chronic conditions with few or no disease-modifying therapeutics available. Advances in genome engineering technology, most recently with CRISPR-Cas9, have revolutionized our ability to interrogate and validate genetic and epigenetic elements associated with chronic diseases such as arthritis. These technologies, together with cell reprogramming methods, including the use of induced pluripotent stem cells, provide a platform for human disease modeling. We summarize new evidence from genome-wide association studies and genomics that substantiates a genetic basis for arthritis pathogenesis. We also review the potential contributions of genome engineering in the development of new arthritis therapeutics.

Duke Scholars

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Published In

Trends in molecular medicine

DOI

EISSN

1471-499X

ISSN

1471-4914

Publication Date

October 2017

Volume

23

Issue

10

Start / End Page

917 / 931

Related Subject Headings

  • Precision Medicine
  • Immunology
  • Humans
  • Genome-Wide Association Study
  • Genome, Human
  • Gene Editing
  • CRISPR-Cas Systems
  • Arthritis
  • Animals
  • 42 Health sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Adkar, S. S., Brunger, J. M., Willard, V. P., Wu, C.-L., Gersbach, C. A., & Guilak, F. (2017). Genome Engineering for Personalized Arthritis Therapeutics. Trends in Molecular Medicine, 23(10), 917–931. https://doi.org/10.1016/j.molmed.2017.08.002
Adkar, Shaunak S., Jonathan M. Brunger, Vincent P. Willard, Chia-Lung Wu, Charles A. Gersbach, and Farshid Guilak. “Genome Engineering for Personalized Arthritis Therapeutics.Trends in Molecular Medicine 23, no. 10 (October 2017): 917–31. https://doi.org/10.1016/j.molmed.2017.08.002.
Adkar SS, Brunger JM, Willard VP, Wu C-L, Gersbach CA, Guilak F. Genome Engineering for Personalized Arthritis Therapeutics. Trends in molecular medicine. 2017 Oct;23(10):917–31.
Adkar, Shaunak S., et al. “Genome Engineering for Personalized Arthritis Therapeutics.Trends in Molecular Medicine, vol. 23, no. 10, Oct. 2017, pp. 917–31. Epmc, doi:10.1016/j.molmed.2017.08.002.
Adkar SS, Brunger JM, Willard VP, Wu C-L, Gersbach CA, Guilak F. Genome Engineering for Personalized Arthritis Therapeutics. Trends in molecular medicine. 2017 Oct;23(10):917–931.
Journal cover image

Published In

Trends in molecular medicine

DOI

EISSN

1471-499X

ISSN

1471-4914

Publication Date

October 2017

Volume

23

Issue

10

Start / End Page

917 / 931

Related Subject Headings

  • Precision Medicine
  • Immunology
  • Humans
  • Genome-Wide Association Study
  • Genome, Human
  • Gene Editing
  • CRISPR-Cas Systems
  • Arthritis
  • Animals
  • 42 Health sciences