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Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging.

Publication ,  Journal Article
Ivanov, A; Dabiesingh, DS; Bhumireddy, GP; Mohamed, A; Asfour, A; Briggs, WM; Ho, J; Khan, SA; Grossman, A; Klem, I; Sacchi, TJ; Heitner, JF
Published in: Circ Cardiovasc Imaging
September 2017

BACKGROUND: Presence of prominent left ventricular trabeculation satisfying criteria for left ventricular noncompaction (LVNC) on routine cardiac magnetic resonance examination is frequently encountered; however, the clinical and prognostic significance of these findings remain elusive. This registry aimed to assess LVNC prevalence by 4 current criteria and to prospectively evaluate an association between diagnosis of LVNC by these criteria and adverse events. METHODS AND RESULTS: There were 700 patients referred for cardiac magnetic resonance: 42% were women, median age was 70 years (range, 45-71 years), mean left ventricular ejection fraction was 51% (±17%), and 32% had late gadolinium enhancement on cardiac magnetic resonance. The cohort underwent diagnostic assessment for LVNC by 4 separate imaging criteria-referenced by their authors as Petersen, Stacey, Jacquier, and Captur, with LVNC prevalence of 39%, 23%, 25% and 3%, respectively. Primary clinical outcome was combined end point of time to death, ischemic stroke, ventricular tachycardia/ventricular fibrillation, and heart failure hospitalization. Secondary clinical outcomes were (1) all-cause mortality and (2) time to the first occurrence of any of the following events: cardiac death, ischemic stroke, ventricular tachycardia/ventricular fibrillation, or heart failure hospitalization. During a median follow-up of 7 years, there were no statistically significant differences in assessed outcomes noted between patients with and without LVNC irrespective of the applied criteria. CONCLUSIONS: Current criteria for the diagnosis of LVNC leads to highly variable disease prevalence in patients referred for cardiac magnetic resonance. The diagnosis of LVNC, by any current criteria, was not associated with adverse clinical events on nearly 7 years of follow-up. Limited conclusions can be made for Captur criteria due to low observed prevalence.

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Published In

Circ Cardiovasc Imaging

DOI

EISSN

1942-0080

Publication Date

September 2017

Volume

10

Issue

9

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Fibrillation
  • Time Factors
  • Tachycardia, Ventricular
  • Stroke Volume
  • Stroke
  • Risk Factors
  • Reproducibility of Results
  • Registries
  • Referral and Consultation
 

Citation

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Ivanov, A., Dabiesingh, D. S., Bhumireddy, G. P., Mohamed, A., Asfour, A., Briggs, W. M., … Heitner, J. F. (2017). Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging. Circ Cardiovasc Imaging, 10(9). https://doi.org/10.1161/CIRCIMAGING.117.006174
Ivanov, Alexander, Devindra S. Dabiesingh, Geetha P. Bhumireddy, Ambreen Mohamed, Ahmed Asfour, William M. Briggs, Jean Ho, et al. “Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging.Circ Cardiovasc Imaging 10, no. 9 (September 2017). https://doi.org/10.1161/CIRCIMAGING.117.006174.
Ivanov A, Dabiesingh DS, Bhumireddy GP, Mohamed A, Asfour A, Briggs WM, et al. Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging. Circ Cardiovasc Imaging. 2017 Sep;10(9).
Ivanov, Alexander, et al. “Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging.Circ Cardiovasc Imaging, vol. 10, no. 9, Sept. 2017. Pubmed, doi:10.1161/CIRCIMAGING.117.006174.
Ivanov A, Dabiesingh DS, Bhumireddy GP, Mohamed A, Asfour A, Briggs WM, Ho J, Khan SA, Grossman A, Klem I, Sacchi TJ, Heitner JF. Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging. Circ Cardiovasc Imaging. 2017 Sep;10(9).

Published In

Circ Cardiovasc Imaging

DOI

EISSN

1942-0080

Publication Date

September 2017

Volume

10

Issue

9

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Ventricular Fibrillation
  • Time Factors
  • Tachycardia, Ventricular
  • Stroke Volume
  • Stroke
  • Risk Factors
  • Reproducibility of Results
  • Registries
  • Referral and Consultation