Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.


Journal Article (Review)

The emergence of drug-resistant fungi poses a major threat to human health. Despite advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections continue to cause significant morbidity and mortality in patients with compromised immunity, underscoring the urgent need for new antifungal agents. In this article, we review the challenges associated with identifying broad-spectrum antifungal drugs and highlight novel targets that could enhance the armamentarium of agents available to treat drug-resistant invasive fungal infections.

Full Text

Duke Authors

Cited Authors

  • McCarthy, MW; Kontoyiannis, DP; Cornely, OA; Perfect, JR; Walsh, TJ

Published Date

  • August 15, 2017

Published In

Volume / Issue

  • 216 / suppl_3

Start / End Page

  • S474 - S483

PubMed ID

  • 28911042

Pubmed Central ID

  • 28911042

Electronic International Standard Serial Number (EISSN)

  • 1537-6613

Digital Object Identifier (DOI)

  • 10.1093/infdis/jix130


  • eng

Conference Location

  • United States