Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study.

Published

Journal Article

BACKGROUND/AIM: To evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes. METHODS: A 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion. RESULTS: The study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men's wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders. CONCLUSIONS: IL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.

Full Text

Duke Authors

Cited Authors

  • Terrell, TR; Abramson, R; Barth, JT; Bennett, E; Cantu, RC; Sloane, R; Laskowitz, DT; Erlanger, DM; McKeag, D; Nichols, G; Valentine, V; Galloway, L

Published Date

  • February 2018

Published In

Volume / Issue

  • 52 / 3

Start / End Page

  • 192 - 198

PubMed ID

  • 28918391

Pubmed Central ID

  • 28918391

Electronic International Standard Serial Number (EISSN)

  • 1473-0480

Digital Object Identifier (DOI)

  • 10.1136/bjsports-2016-097419

Language

  • eng

Conference Location

  • England