Microtubule organization, dynamics and functions in differentiated cells.

Journal Article (Journal Article;Review)

Over the past several decades, numerous studies have greatly expanded our knowledge about how microtubule organization and dynamics are controlled in cultured cells in vitro However, our understanding of microtubule dynamics and functions in vivo, in differentiated cells and tissues, remains under-explored. Recent advances in generating genetic tools and imaging technologies to probe microtubules in situ, coupled with an increased interest in the functions of this cytoskeletal network in differentiated cells, are resulting in a renaissance. Here, we discuss the lessons learned from such approaches, which have revealed that, although some differentiated cells utilize conserved strategies to remodel microtubules, there is considerable diversity in the underlying molecular mechanisms of microtubule reorganization. This highlights a continued need to explore how differentiated cells regulate microtubule geometry in vivo.

Full Text

Duke Authors

Cited Authors

  • Muroyama, A; Lechler, T

Published Date

  • September 1, 2017

Published In

Volume / Issue

  • 144 / 17

Start / End Page

  • 3012 - 3021

PubMed ID

  • 28851722

Pubmed Central ID

  • PMC5611961

Electronic International Standard Serial Number (EISSN)

  • 1477-9129

Digital Object Identifier (DOI)

  • 10.1242/dev.153171


  • eng

Conference Location

  • England