Developing a common framework for evaluating the implementation of genomic medicine interventions in clinical care: the IGNITE Network's Common Measures Working Group.

Journal Article (Journal Article)

PurposeImplementation research provides a structure for evaluating the clinical integration of genomic medicine interventions. This paper describes the Implementing Genomics in Practice (IGNITE) Network's efforts to promote (i) a broader understanding of genomic medicine implementation research and (ii) the sharing of knowledge generated in the network.MethodsTo facilitate this goal, the IGNITE Network Common Measures Working Group (CMG) members adopted the Consolidated Framework for Implementation Research (CFIR) to guide its approach to identifying constructs and measures relevant to evaluating genomic medicine as a whole, standardizing data collection across projects, and combining data in a centralized resource for cross-network analyses.ResultsCMG identified 10 high-priority CFIR constructs as important for genomic medicine. Of those, eight did not have standardized measurement instruments. Therefore, we developed four survey tools to address this gap. In addition, we identified seven high-priority constructs related to patients, families, and communities that did not map to CFIR constructs. Both sets of constructs were combined to create a draft genomic medicine implementation model.ConclusionWe developed processes to identify constructs deemed valuable for genomic medicine implementation and codified them in a model. These resources are freely available to facilitate knowledge generation and sharing across the field.

Full Text

Duke Authors

Cited Authors

  • Orlando, LA; Sperber, NR; Voils, C; Nichols, M; Myers, RA; Wu, RR; Rakhra-Burris, T; Levy, KD; Levy, M; Pollin, TI; Guan, Y; Horowitz, CR; Ramos, M; Kimmel, SE; McDonough, CW; Madden, EB; Damschroder, LJ

Published Date

  • June 2018

Published In

Volume / Issue

  • 20 / 6

Start / End Page

  • 655 - 663

PubMed ID

  • 28914267

Pubmed Central ID

  • PMC5851794

Electronic International Standard Serial Number (EISSN)

  • 1530-0366

Digital Object Identifier (DOI)

  • 10.1038/gim.2017.144


  • eng

Conference Location

  • United States