Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections.


Journal Article (Review)

Human cytomegalovirus (HCMV) is the leading opportunistic viral infection in solid organ transplant patients and is the most common congenitally transmitted pathogen worldwide. Despite the significant burden of disease HCMV causes in immunosuppressed patients and infected newborns, there are no licensed preventative vaccines or effective immunotherapeutic treatments for HCMV, largely due to our incomplete understanding of the immune correlates of protection against HCMV infection and disease. Though CMV species-specificity imposes an additional challenge in defining a suitable animal model for HCMV, nonhuman primate (NHP) CMVs are the most genetically related to HCMV. In this review, we discuss the advantages and applicability of rhesus monkey models for studying HCMV infections and pathogenesis and ultimately informing vaccine development.

Full Text

Duke Authors

Cited Authors

  • Itell, HL; Kaur, A; Deere, JD; Barry, PA; Permar, SR

Published Date

  • August 2017

Published In

Volume / Issue

  • 25 /

Start / End Page

  • 126 - 133

PubMed ID

  • 28888133

Pubmed Central ID

  • 28888133

Electronic International Standard Serial Number (EISSN)

  • 1879-6265

International Standard Serial Number (ISSN)

  • 1879-6257

Digital Object Identifier (DOI)

  • 10.1016/j.coviro.2017.08.005


  • eng