Copper Acquisition and Utilization in Fungi.

Published

Journal Article (Review)

Fungal cells colonize and proliferate in distinct niches, from soil and plants to diverse tissues in human hosts. Consequently, fungi are challenged with the goal of obtaining nutrients while simultaneously elaborating robust regulatory mechanisms to cope with a range of availability of nutrients, from scarcity to excess. Copper is essential for life but also potentially toxic. In this review we describe the sophisticated homeostatic mechanisms by which fungi acquire, utilize, and control this biochemically versatile trace element. Fungal pathogens, which can occupy distinct host tissues that have their own intrinsic requirements for copper homeostasis, have evolved mechanisms to acquire copper to successfully colonize the host, disseminate to other tissues, and combat host copper bombardment mechanisms that would otherwise mitigate virulence.

Full Text

Duke Authors

Cited Authors

  • Smith, AD; Logeman, BL; Thiele, DJ

Published Date

  • September 8, 2017

Published In

Volume / Issue

  • 71 /

Start / End Page

  • 597 - 623

PubMed ID

  • 28886682

Pubmed Central ID

  • 28886682

Electronic International Standard Serial Number (EISSN)

  • 1545-3251

Digital Object Identifier (DOI)

  • 10.1146/annurev-micro-030117-020444

Language

  • eng

Conference Location

  • United States