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Gene Ontology annotations and resources.

Publication ,  Journal Article
Gene Ontology Consortium, ; Blake, JA; Dolan, M; Drabkin, H; Hill, DP; Li, N; Sitnikov, D; Bridges, S; Burgess, S; Buza, T; McCarthy, F; Mi, H ...
Published in: Nucleic Acids Res
January 2013
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The Gene Ontology (GO) Consortium (GOC, http://www.geneontology.org) is a community-based bioinformatics resource that classifies gene product function through the use of structured, controlled vocabularies. Over the past year, the GOC has implemented several processes to increase the quantity, quality and specificity of GO annotations. First, the number of manual, literature-based annotations has grown at an increasing rate. Second, as a result of a new 'phylogenetic annotation' process, manually reviewed, homology-based annotations are becoming available for a broad range of species. Third, the quality of GO annotations has been improved through a streamlined process for, and automated quality checks of, GO annotations deposited by different annotation groups. Fourth, the consistency and correctness of the ontology itself has increased by using automated reasoning tools. Finally, the GO has been expanded not only to cover new areas of biology through focused interaction with experts, but also to capture greater specificity in all areas of the ontology using tools for adding new combinatorial terms. The GOC works closely with other ontology developers to support integrated use of terminologies. The GOC supports its user community through the use of e-mail lists, social media and web-based resources.

Duke Scholars

Warren Alden Kibbe
Author Warren Alden Kibbe Biostatistics & Bioinformatics, Division of Translational Bi ...
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Published In

Nucleic Acids Res

DOI

10.1093/nar/gks1050

EISSN

1362-4962

Publication Date

January 2013

Volume

41

Issue

Database issue

Start / End Page

D530 / D535

Location

England

Related Subject Headings

  • Vocabulary, Controlled
  • Phylogeny
  • Molecular Sequence Annotation
  • Internet
  • Genes
  • Developmental Biology
  • Databases, Genetic
  • 41 Environmental sciences
  • 34 Chemical sciences
  • 31 Biological sciences
 

Citation

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ICMJE
MLA
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Gene Ontology Consortium, ., Blake, J. A., Dolan, M., Drabkin, H., Hill, D. P., Li, N., … Westerfield, M. (2013). Gene Ontology annotations and resources. Nucleic Acids Res, 41(Database issue), D530–D535. https://doi.org/10.1093/nar/gks1050
Gene Ontology Consortium, M., J. A. Blake, M. Dolan, H. Drabkin, D. P. Hill, Ni Li, D. Sitnikov, et al. “Gene Ontology annotations and resources.” Nucleic Acids Res 41, no. Database issue (January 2013): D530–35. https://doi.org/10.1093/nar/gks1050.
Gene Ontology Consortium, Blake JA, Dolan M, Drabkin H, Hill DP, Li N, et al. Gene Ontology annotations and resources. Nucleic Acids Res. 2013 Jan;41(Database issue):D530–5.
Gene Ontology Consortium, M., et al. “Gene Ontology annotations and resources.” Nucleic Acids Res, vol. 41, no. Database issue, Jan. 2013, pp. D530–35. Pubmed, doi:10.1093/nar/gks1050.
Gene Ontology Consortium, Blake JA, Dolan M, Drabkin H, Hill DP, Li N, Sitnikov D, Bridges S, Burgess S, Buza T, McCarthy F, Peddinti D, Pillai L, Carbon S, Dietze H, Ireland A, Lewis SE, Mungall CJ, Gaudet P, Chrisholm RL, Fey P, Kibbe WA, Basu S, Siegele DA, McIntosh BK, Renfro DP, Zweifel AE, Hu JC, Brown NH, Tweedie S, Alam-Faruque Y, Apweiler R, Auchinchloss A, Axelsen K, Bely B, Blatter M-C, Bonilla C, Bouguerleret L, Boutet E, Breuza L, Bridge A, Chan WM, Chavali G, Coudert E, Dimmer E, Estreicher A, Famiglietti L, Feuermann M, Gos A, Gruaz-Gumowski N, Hieta R, Hinz C, Hulo C, Huntley R, James J, Jungo F, Keller G, Laiho K, Legge D, Lemercier P, Lieberherr D, Magrane M, Martin MJ, Masson P, Mutowo-Muellenet P, O’Donovan C, Pedruzzi I, Pichler K, Poggioli D, Porras Millán P, Poux S, Rivoire C, Roechert B, Sawford T, Schneider M, Stutz A, Sundaram S, Tognolli M, Xenarios I, Foulgar R, Lomax J, Roncaglia P, Khodiyar VK, Lovering RC, Talmud PJ, Chibucos M, Giglio MG, Chang H-Y, Hunter S, McAnulla C, Mitchell A, Sangrador A, Stephan R, Harris MA, Oliver SG, Rutherford K, Wood V, Bahler J, Lock A, Kersey PJ, McDowall DM, Staines DM, Dwinell M, Shimoyama M, Laulederkind S, Hayman T, Wang S-J, Petri V, Lowry T, D’Eustachio P, Matthews L, Balakrishnan R, Binkley G, Cherry JM, Costanzo MC, Dwight SS, Engel SR, Fisk DG, Hitz BC, Hong EL, Karra K, Miyasato SR, Nash RS, Park J, Skrzypek MS, Weng S, Wong ED, Berardini TZ, Huala E, Mi H, Thomas PD, Chan J, Kishore R, Sternberg P, Van Auken K, Howe D, Westerfield M. Gene Ontology annotations and resources. Nucleic Acids Res. 2013 Jan;41(Database issue):D530–D535.
Journal cover image

Published In

Nucleic Acids Res

DOI

10.1093/nar/gks1050

EISSN

1362-4962

Publication Date

January 2013

Volume

41

Issue

Database issue

Start / End Page

D530 / D535

Location

England

Related Subject Headings

  • Vocabulary, Controlled
  • Phylogeny
  • Molecular Sequence Annotation
  • Internet
  • Genes
  • Developmental Biology
  • Databases, Genetic
  • 41 Environmental sciences
  • 34 Chemical sciences
  • 31 Biological sciences