Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.

Published

Journal Article

The incidence and severity of obesity and type 2 diabetes are increasing in Western societies. The progression of obesity to type 2 diabetes is gradual with overlapping symptoms of insulin resistance, hyperinsulinemia, hyperglycemia, dyslipidemias, ion imbalance, and inflammation; this complex syndrome has been called diabesity. We describe here comparisons of gene expression in livers of A/a (agouti) vs. A(vy)/A (obese yellow) segregants (i.e., littermates) from BALB/cStCrlfC3H/Nctr x VYWffC3Hf/Nctr-A(vy)/a matings in response to 70% and 100% of ad libitum caloric intakes of a reproducible diet. Twenty-eight (28) genes regulated by diet, genotype, or diet x genotype interactions mapped to diabesity quantitative trait loci. A subset of the identified genes is linked to abnormal physiological signs observed in obesity and diabetes.

Full Text

Duke Authors

Cited Authors

  • Kaput, J; Klein, KG; Reyes, EJ; Kibbe, WA; Cooney, CA; Jovanovic, B; Visek, WJ; Wolff, GL

Published Date

  • August 11, 2004

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 316 - 324

PubMed ID

  • 15306695

Pubmed Central ID

  • 15306695

Electronic International Standard Serial Number (EISSN)

  • 1531-2267

International Standard Serial Number (ISSN)

  • 1094-8341

Digital Object Identifier (DOI)

  • 10.1152/physiolgenomics.00065.2003

Language

  • eng