Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
Journal Article (Journal Article)
The incidence and severity of obesity and type 2 diabetes are increasing in Western societies. The progression of obesity to type 2 diabetes is gradual with overlapping symptoms of insulin resistance, hyperinsulinemia, hyperglycemia, dyslipidemias, ion imbalance, and inflammation; this complex syndrome has been called diabesity. We describe here comparisons of gene expression in livers of A/a (agouti) vs. A(vy)/A (obese yellow) segregants (i.e., littermates) from BALB/cStCrlfC3H/Nctr x VYWffC3Hf/Nctr-A(vy)/a matings in response to 70% and 100% of ad libitum caloric intakes of a reproducible diet. Twenty-eight (28) genes regulated by diet, genotype, or diet x genotype interactions mapped to diabesity quantitative trait loci. A subset of the identified genes is linked to abnormal physiological signs observed in obesity and diabetes.
Full Text
Duke Authors
Cited Authors
- Kaput, J; Klein, KG; Reyes, EJ; Kibbe, WA; Cooney, CA; Jovanovic, B; Visek, WJ; Wolff, GL
Published Date
- August 11, 2004
Published In
Volume / Issue
- 18 / 3
Start / End Page
- 316 - 324
PubMed ID
- 15306695
Electronic International Standard Serial Number (EISSN)
- 1531-2267
Digital Object Identifier (DOI)
- 10.1152/physiolgenomics.00065.2003
Language
- eng
Conference Location
- United States