Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function.

Journal Article (Journal Article;Review)

N-ethyl-N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype screens that assess nervous system structure and function. In particular, these screens focus on complex behavioral traits from drug and alcohol responses to circadian rhythms to epilepsy. Each of these centers has developed a bioinformatics infrastructure to track the extensive number of transactions that are inherent in these large-scale projects. Over 100 new mouse mutant lines have been defined through the efforts of these three mutagenesis centers and are presented to the research community via the centralized Web presence of the consortium ( This community resource provides visitors with the ability to search for specific mutant phenotypes, to view the genetic and phenotypic details of mutant mouse lines, and to order these mice for use in their own research program.

Full Text

Duke Authors

Cited Authors

  • Goldowitz, D; Frankel, WN; Takahashi, JS; Holtz-Vitaterna, M; Bult, C; Kibbe, WA; Snoddy, J; Li, Y; Pretel, S; Yates, J; Swanson, DJ

Published Date

  • December 20, 2004

Published In

Volume / Issue

  • 132 / 2

Start / End Page

  • 105 - 115

PubMed ID

  • 15582151

Pubmed Central ID

  • PMC3773686

International Standard Serial Number (ISSN)

  • 0169-328X

Digital Object Identifier (DOI)

  • 10.1016/j.molbrainres.2004.09.016


  • eng

Conference Location

  • Netherlands