Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis.
Publication
, Journal Article
Gospe, SM; Caruso, RD; Clegg, MS; Keen, CL; Pimstone, NR; Ducore, JM; Gettner, SS; Kreutzer, RA
Published in: Arch Dis Child
November 2000
Progressive myelopathy is a rare complication of chronic hepatic disease which has never been reported in the paediatric age group. We describe the 11 year course of an adolescent male with hepatic myelopathy caused by cryptogenic micronodular cirrhosis. His condition has been associated with persistent polycythaemia and extraordinary increases of whole blood manganese, with magnetic resonance imaging evidence of manganese deposition within the basal ganglia and other regions of the brain. The patient has developed neither liver failure nor parkinsonism. The pathophysiological bases of this multiorgan system disorder are described.
Duke Scholars
Published In
Arch Dis Child
DOI
EISSN
1468-2044
Publication Date
November 2000
Volume
83
Issue
5
Start / End Page
439 / 442
Location
England
Related Subject Headings
- Polycythemia
- Pediatrics
- Paraparesis, Spastic
- Manganese
- Male
- Liver Cirrhosis
- Humans
- Follow-Up Studies
- Chronic Disease
- Adolescent
Citation
APA
Chicago
ICMJE
MLA
NLM
Gospe, S. M., Caruso, R. D., Clegg, M. S., Keen, C. L., Pimstone, N. R., Ducore, J. M., … Kreutzer, R. A. (2000). Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis. Arch Dis Child, 83(5), 439–442. https://doi.org/10.1136/adc.83.5.439
Gospe, S. M., R. D. Caruso, M. S. Clegg, C. L. Keen, N. R. Pimstone, J. M. Ducore, S. S. Gettner, and R. A. Kreutzer. “Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis.” Arch Dis Child 83, no. 5 (November 2000): 439–42. https://doi.org/10.1136/adc.83.5.439.
Gospe SM, Caruso RD, Clegg MS, Keen CL, Pimstone NR, Ducore JM, et al. Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis. Arch Dis Child. 2000 Nov;83(5):439–42.
Gospe, S. M., et al. “Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis.” Arch Dis Child, vol. 83, no. 5, Nov. 2000, pp. 439–42. Pubmed, doi:10.1136/adc.83.5.439.
Gospe SM, Caruso RD, Clegg MS, Keen CL, Pimstone NR, Ducore JM, Gettner SS, Kreutzer RA. Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis. Arch Dis Child. 2000 Nov;83(5):439–442.
Published In
Arch Dis Child
DOI
EISSN
1468-2044
Publication Date
November 2000
Volume
83
Issue
5
Start / End Page
439 / 442
Location
England
Related Subject Headings
- Polycythemia
- Pediatrics
- Paraparesis, Spastic
- Manganese
- Male
- Liver Cirrhosis
- Humans
- Follow-Up Studies
- Chronic Disease
- Adolescent