Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis.

Journal Article (Journal Article)

Progressive myelopathy is a rare complication of chronic hepatic disease which has never been reported in the paediatric age group. We describe the 11 year course of an adolescent male with hepatic myelopathy caused by cryptogenic micronodular cirrhosis. His condition has been associated with persistent polycythaemia and extraordinary increases of whole blood manganese, with magnetic resonance imaging evidence of manganese deposition within the basal ganglia and other regions of the brain. The patient has developed neither liver failure nor parkinsonism. The pathophysiological bases of this multiorgan system disorder are described.

Full Text

Duke Authors

Cited Authors

  • Gospe, SM; Caruso, RD; Clegg, MS; Keen, CL; Pimstone, NR; Ducore, JM; Gettner, SS; Kreutzer, RA

Published Date

  • November 2000

Published In

Volume / Issue

  • 83 / 5

Start / End Page

  • 439 - 442

PubMed ID

  • 11040156

Pubmed Central ID

  • PMC1718535

Electronic International Standard Serial Number (EISSN)

  • 1468-2044

Digital Object Identifier (DOI)

  • 10.1136/adc.83.5.439


  • eng

Conference Location

  • England