Stable-isotope dilution GC-MS for determination of toluene in submilliliter volumes of whole blood.

Journal Article (Journal Article)

An accurate and sensitive yet simple protocol for the analysis of toluene in submilliliter quantities of whole blood using stable-isotope dilution GC-MS has been developed and evaluated for use in pharmacokinetic studies of toluene exposure. The method involves the use of toluene-d8, a relatively inexpensive chemical used as a solvent for nuclear magnetic resonance spectroscopy, as an internal standard and extraction with pentane. This procedure allows for the determination of toluene in whole blood down to approximately 5 ng/mL and is suitable for pharmacokinetic measurements and biomonitoring of exposure to toluene.

Full Text

Duke Authors

Cited Authors

  • Jones, AD; Dunlap, MR; Gospe, SM

Published Date

  • September 1, 1994

Published In

Volume / Issue

  • 18 / 5

Start / End Page

  • 251 - 254

PubMed ID

  • 7990441

International Standard Serial Number (ISSN)

  • 0146-4760

Digital Object Identifier (DOI)

  • 10.1093/jat/18.5.251


  • eng

Conference Location

  • England