Acute vincristine neurotoxicity in the presence of hereditary motor and sensory neuropathy type I.


Journal Article (Review)

Acute vincristine neurotoxicity leading to a severe motor and sensory neuropathy has been noted in patients with hereditary motor and sensory neuropathy type I (HMSN-I). The case of a 2-year-old boy with acute lymphocytic leukemia and HMSN-I is reported, and additional cases from the literature are reviewed. Severe vincristine neurotoxicity in patients with HMSN-I may be secondary to impairment of both slow and- fast axonal transport. Vincristine should be used with caution in patients with a family history of polyneuropathy.

Full Text

Duke Authors

Cited Authors

  • McGuire, SA; Gospe, SM; Dahl, G

Published Date

  • 1989

Published In

Volume / Issue

  • 17 / 6

Start / End Page

  • 520 - 523

PubMed ID

  • 2685529

Pubmed Central ID

  • 2685529

International Standard Serial Number (ISSN)

  • 0098-1532

Digital Object Identifier (DOI)

  • 10.1002/mpo.2950170534


  • eng

Conference Location

  • United States