Central nervous system distribution of inhaled toluene.

Journal Article (Journal Article)

The regional central nervous system distribution of inhaled [14C]toluene was studied in the rat. Toluene was detected in all brain regions, with the highest concentrations in the brainstem. The initial uptake of toluene was significantly correlated with the total lipid content of each brain region. Clinical and experimental neurotoxicity of toluene may be due, in part, to an increased concentration of this solvent in lipid-rich brain areas.

Full Text

Duke Authors

Cited Authors

  • Gospe, SM; Calaban, MJ

Published Date

  • October 1988

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • 540 - 545

PubMed ID

  • 3220222

International Standard Serial Number (ISSN)

  • 0272-0590

Digital Object Identifier (DOI)

  • 10.1016/0272-0590(88)90118-2


  • eng

Conference Location

  • United States