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Central nervous system distribution of inhaled toluene.

Publication ,  Journal Article
Gospe, SM; Calaban, MJ
Published in: Fundam Appl Toxicol
October 1988
Published version (DOI) Link to item

The regional central nervous system distribution of inhaled [14C]toluene was studied in the rat. Toluene was detected in all brain regions, with the highest concentrations in the brainstem. The initial uptake of toluene was significantly correlated with the total lipid content of each brain region. Clinical and experimental neurotoxicity of toluene may be due, in part, to an increased concentration of this solvent in lipid-rich brain areas.

Duke Scholars

Sidney M. Gospe Jr.
Author Sidney M. Gospe Jr. Pediatrics, Neurology

Published In

Fundam Appl Toxicol

DOI

10.1016/0272-0590(88)90118-2

ISSN

0272-0590

Publication Date

October 1988

Volume

11

Issue

3

Start / End Page

540 / 545

Location

United States

Related Subject Headings

  • Toxicology
  • Toluene
  • Time Factors
  • Rats
  • Male
  • Liver
  • Lipid Metabolism
  • Central Nervous System
  • Brain Stem
  • Brain Chemistry
 

Citation

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MLA
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Gospe, S. M., & Calaban, M. J. (1988). Central nervous system distribution of inhaled toluene. Fundam Appl Toxicol, 11(3), 540–545. https://doi.org/10.1016/0272-0590(88)90118-2
Gospe, S. M., and M. J. Calaban. “Central nervous system distribution of inhaled toluene.” Fundam Appl Toxicol 11, no. 3 (October 1988): 540–45. https://doi.org/10.1016/0272-0590(88)90118-2.
Gospe SM, Calaban MJ. Central nervous system distribution of inhaled toluene. Fundam Appl Toxicol. 1988 Oct;11(3):540–5.
Gospe, S. M., and M. J. Calaban. “Central nervous system distribution of inhaled toluene.” Fundam Appl Toxicol, vol. 11, no. 3, Oct. 1988, pp. 540–45. Pubmed, doi:10.1016/0272-0590(88)90118-2.
Gospe SM, Calaban MJ. Central nervous system distribution of inhaled toluene. Fundam Appl Toxicol. 1988 Oct;11(3):540–545.

Published In

Fundam Appl Toxicol

DOI

10.1016/0272-0590(88)90118-2

ISSN

0272-0590

Publication Date

October 1988

Volume

11

Issue

3

Start / End Page

540 / 545

Location

United States

Related Subject Headings

  • Toxicology
  • Toluene
  • Time Factors
  • Rats
  • Male
  • Liver
  • Lipid Metabolism
  • Central Nervous System
  • Brain Stem
  • Brain Chemistry