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Regulation of spine structural plasticity by Arc/Arg3.1.

Publication ,  Journal Article
Newpher, TM; Harris, S; Pringle, J; Hamilton, C; Soderling, S
Published in: Semin Cell Dev Biol
May 2018

Dendritic spines are actin-rich, postsynaptic protrusions that contact presynaptic terminals to form excitatory chemical synapses. These synaptic contacts are widely believed to be the sites of memory formation and information storage, and changes in spine shape are thought to underlie several forms of learning-related plasticity. Both membrane trafficking pathways and the actin cytoskeleton drive activity-dependent structural and functional changes in dendritic spines. A key molecular player in regulating these processes is the activity-regulated cytoskeleton-associated protein (Arc), a protein that has diverse roles in expression of synaptic plasticity. In this review, we highlight important findings that have shaped our understanding of Arc's functions in structural and functional plasticity, as well as Arc's contributions to memory consolidation and disease.

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Published In

Semin Cell Dev Biol

DOI

EISSN

1096-3634

Publication Date

May 2018

Volume

77

Start / End Page

25 / 32

Location

England

Related Subject Headings

  • Synapses
  • Neuronal Plasticity
  • Nerve Tissue Proteins
  • Memory
  • Humans
  • Endocytosis
  • Developmental Biology
  • Dendritic Spines
  • Cytoskeletal Proteins
  • Actins
 

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Newpher, T. M., Harris, S., Pringle, J., Hamilton, C., & Soderling, S. (2018). Regulation of spine structural plasticity by Arc/Arg3.1. Semin Cell Dev Biol, 77, 25–32. https://doi.org/10.1016/j.semcdb.2017.09.022
Newpher, Thomas M., Scott Harris, Jasmine Pringle, Colleen Hamilton, and Scott Soderling. “Regulation of spine structural plasticity by Arc/Arg3.1.Semin Cell Dev Biol 77 (May 2018): 25–32. https://doi.org/10.1016/j.semcdb.2017.09.022.
Newpher TM, Harris S, Pringle J, Hamilton C, Soderling S. Regulation of spine structural plasticity by Arc/Arg3.1. Semin Cell Dev Biol. 2018 May;77:25–32.
Newpher, Thomas M., et al. “Regulation of spine structural plasticity by Arc/Arg3.1.Semin Cell Dev Biol, vol. 77, May 2018, pp. 25–32. Pubmed, doi:10.1016/j.semcdb.2017.09.022.
Newpher TM, Harris S, Pringle J, Hamilton C, Soderling S. Regulation of spine structural plasticity by Arc/Arg3.1. Semin Cell Dev Biol. 2018 May;77:25–32.
Journal cover image

Published In

Semin Cell Dev Biol

DOI

EISSN

1096-3634

Publication Date

May 2018

Volume

77

Start / End Page

25 / 32

Location

England

Related Subject Headings

  • Synapses
  • Neuronal Plasticity
  • Nerve Tissue Proteins
  • Memory
  • Humans
  • Endocytosis
  • Developmental Biology
  • Dendritic Spines
  • Cytoskeletal Proteins
  • Actins