Regulation of spine structural plasticity by Arc/Arg3.1.

Journal Article (Journal Article;Review)

Dendritic spines are actin-rich, postsynaptic protrusions that contact presynaptic terminals to form excitatory chemical synapses. These synaptic contacts are widely believed to be the sites of memory formation and information storage, and changes in spine shape are thought to underlie several forms of learning-related plasticity. Both membrane trafficking pathways and the actin cytoskeleton drive activity-dependent structural and functional changes in dendritic spines. A key molecular player in regulating these processes is the activity-regulated cytoskeleton-associated protein (Arc), a protein that has diverse roles in expression of synaptic plasticity. In this review, we highlight important findings that have shaped our understanding of Arc's functions in structural and functional plasticity, as well as Arc's contributions to memory consolidation and disease.

Full Text

Duke Authors

Cited Authors

  • Newpher, TM; Harris, S; Pringle, J; Hamilton, C; Soderling, S

Published Date

  • May 2018

Published In

Volume / Issue

  • 77 /

Start / End Page

  • 25 - 32

PubMed ID

  • 28943393

Electronic International Standard Serial Number (EISSN)

  • 1096-3634

Digital Object Identifier (DOI)

  • 10.1016/j.semcdb.2017.09.022


  • eng

Conference Location

  • England