Application of biological markers in depression secondary to thyrotoxicosis.


Journal Article

Biological markers of affective disorders have not been studied intensively in patients with secondary depression. An elderly woman with severe delusional depression secondary to thyrotoxicosis was monitored with weekly dexamethasone suppression tests (DSTs) and three sleep electroencephalography (EEG) evaluations. She received treatment only for her thyrotoxicosis, but her depression resolved completely. The serial DSTs were normal throughout her depression, consistent with the specificity of this test for primary endogenous depression. The sleep EEG erroneously suggested a diagnosis of primary depression but effectively monitored clinical improvement. Biological markers may have applicability in evaluating and monitoring patients with secondary depression.

Full Text

Cited Authors

  • Kronfol, Z; Greden, JF; Condon, M; Feinberg, M; Carroll, BJ

Published Date

  • October 1, 1982

Published In

Volume / Issue

  • 139 / 10

Start / End Page

  • 1319 - 1322

PubMed ID

  • 7124985

Pubmed Central ID

  • 7124985

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/ajp.139.10.1319


  • eng

Conference Location

  • United States