Rubidium and lithium: opposite effects on amine-mediated excitement.


Journal Article

In mice the activation caused by morphine was antagonized by previous treatment with lithium and was potentiated by previous treatment with rubidium. Other antimanic drugs antagonized the morphine activation as well. The effect of rubidium was similar to that of the antidepressant drugs imipramine and pargyline. Rubidium may merit clinical evaluation as an antidepressant agent in man.

Full Text

Cited Authors

  • Carroll, BJ; Sharp, PT

Published Date

  • June 25, 1971

Published In

Volume / Issue

  • 172 / 3990

Start / End Page

  • 1355 - 1357

PubMed ID

  • 5103943

Pubmed Central ID

  • 5103943

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.172.3990.1355


  • eng

Conference Location

  • United States