Serotonin transporter gene polymorphism and antidepressant response.


Journal Article

We examined allelic polymorphisms of the serotonin transporter (5-HTT) gene and antidepressant response to 6 weeks' treatment with the selective serotonin reuptake inhibitor (SSRI) drugs fluoxetine or paroxetine. We genotyped 120 patients and 252 normal controls, using polymerase chain reaction of genomic DNA with primers flanking the second intron and promoter regions of the 5-HTT gene. Diagnosis of depression was not associated with 5-HTT polymorphisms. Patients homozygous l/l in intron 2 or homozygous s/s in the promoter region showed better responses than all others (p < 0.0001, p = 0.0074, respectively). Lack of the l/l allele form in intron 2 most powerfully predicted non-response (83.3%). Response to SSRI drugs is related to allelic variation in the 5-HTT gene in depressed Korean patients.

Full Text

Cited Authors

  • Kim, DK; Lim, SW; Lee, S; Sohn, SE; Kim, S; Hahn, CG; Carroll, BJ

Published Date

  • January 17, 2000

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 215 - 219

PubMed ID

  • 10683861

Pubmed Central ID

  • 10683861

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-200001170-00042


  • eng

Conference Location

  • England