Paradoxical response to dopamine agonists in tardive dyskinesia.


Journal Article

The authors conducted an extensive pharmacological analysis of a patient severely affected by tardive dyskinesia. No drug treatment gave lasting clinical improvement. Several agents recently recommended for this condition, dimethyl aminoethanol, clozapine, and thioridazine, failed to modify the dyskinesia. Reserpine caused a worsening of the symptoms. A paradoxical and unexpected improvement was observed with apomorphine injections and with low-dosage oral L-dopa. These two drugs may have acted by stimulating presynaptic inhibitory dopamine receptors.

Full Text

Cited Authors

  • Carroll, BJ; Curtis, GC; Kokmen, E

Published Date

  • July 1, 1977

Published In

Volume / Issue

  • 134 / 7

Start / End Page

  • 785 - 789

PubMed ID

  • 17308

Pubmed Central ID

  • 17308

International Standard Serial Number (ISSN)

  • 0002-953X

Digital Object Identifier (DOI)

  • 10.1176/ajp.134.7.785


  • eng

Conference Location

  • United States