Hypothalamic-pituitary-adrenocortical activity in patients with diabetes mellitus.


Journal Article

Several clinical and physiologic associations between depression and diabetes mellitus have been reported. In this study, a potential neuroendocrine association was studied by measuring hypothalamic-pituitary-adrenocortical (HPA) axis activity in patients with diabetes mellitus. Plasma cortisol levels and response to dexamethasone administration were determined in 54 diabetics. Twenty-three (55%) of forty-two 1-mg dexamethasone suppression tests (DSTs) performed in 34 subjects, with eight repeated tests, and two (10%) of twenty 2-mg DSTs demonstrated a blunting of normal suppression. None of a variety of potential demographic, physiologic, or mood factors predicted nonsuppression. This study replicates prior findings that HPA dysfunction occurs in association with diabetes, and invalidates the use of the 1-mg DST as a diagnostic marker for melancholia in patients with diabetes.

Full Text

Cited Authors

  • Cameron, OG; Kronfol, Z; Greden, JF; Carroll, BJ

Published Date

  • November 1, 1984

Published In

Volume / Issue

  • 41 / 11

Start / End Page

  • 1090 - 1095

PubMed ID

  • 6497572

Pubmed Central ID

  • 6497572

International Standard Serial Number (ISSN)

  • 0003-990X

Digital Object Identifier (DOI)

  • 10.1001/archpsyc.1983.01790220080013


  • eng

Conference Location

  • United States