Biological markers for endogenous depression in series and parallel.


Journal Article

Several authors have shown that endogenous depressed patients have biological abnormalities which exist to a lesser extent in nonendogenous depressives and in normals, and have suggested that these biological abnormalities may be used as markers to classify depressed patients as endogenous or nonendogenous. We have investigated several of these biological abnormalities, and have explored the diagnostic classifications based on individual markers and on two or more markers in combination. The evaluation of combinations of diagnostic tests requires different statistical techniques than does the evaluation of single tests, and we discuss two such techniques: stepwise multiple regression and contingency table analysis. We report here our results with the dexamethasone suppression test (DST), EEG studies of sleep, and the amphetamine-stimulated release of growth hormone separately and in combination. The amphetamine-stimulated release of growth hormone was not diagnostically useful.

Full Text

Cited Authors

  • Feinberg, M; Carroll, BJ

Published Date

  • January 1, 1984

Published In

Volume / Issue

  • 19 / 1

Start / End Page

  • 3 - 11

PubMed ID

  • 6704459

Pubmed Central ID

  • 6704459

International Standard Serial Number (ISSN)

  • 0006-3223


  • eng

Conference Location

  • United States