Adrenergic control of motor activity: effects of PNMT inhibition upon open field behavior in the rat.


Journal Article

Two inhibitors of brain PNMT were given to rats in doses which caused equivalent reductions in enzyme activity. Each drug produced similar and dose-related decreases in ambulation, rearing and defecation during open field behavioral testing. Central adrenergic (epinephrine containing) system may be necessary for normal open field behavior. This may reflect an interaction with other monoamines, particularly dopamine.

Full Text

Cited Authors

  • Katz, RJ; Turner, BB; Roth, K; Carroll, BJ

Published Date

  • October 1978

Published In

Volume / Issue

  • 9 / 4

Start / End Page

  • 417 - 420

PubMed ID

  • 733828

Pubmed Central ID

  • 733828

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(78)90033-3


  • eng

Conference Location

  • United States