Adrenergic control of motor activity: effects of PNMT inhibition upon open field behavior in the rat.
Published
Journal Article
Two inhibitors of brain PNMT were given to rats in doses which caused equivalent reductions in enzyme activity. Each drug produced similar and dose-related decreases in ambulation, rearing and defecation during open field behavioral testing. Central adrenergic (epinephrine containing) system may be necessary for normal open field behavior. This may reflect an interaction with other monoamines, particularly dopamine.
Full Text
Cited Authors
- Katz, RJ; Turner, BB; Roth, K; Carroll, BJ
Published Date
- October 1978
Published In
Volume / Issue
- 9 / 4
Start / End Page
- 417 - 420
PubMed ID
- 733828
Pubmed Central ID
- 733828
International Standard Serial Number (ISSN)
- 0091-3057
Digital Object Identifier (DOI)
- 10.1016/0091-3057(78)90033-3
Language
- eng
Conference Location
- United States