Affective illness and HLA frequencies: no compelling association.


Journal Article

114 patients suffering from an endogenomorphic affective illness were typed for HLA antigens at the A and B loci, and the frequencies were compared with those of a control panel numbering 439 individuals. Using new analytical procedures, a large number of tests were conducted, but no convincing evidence for an association of HLA types with affective disorders was obtained. A reanalysis of the same data, where patients are classified according to Danish diagnostic criteria, yields a marginally significant association of the B locus alleles. The sample sizes for this latter analysis were small, the test criteria are undoubtedly inflated, and no compelling case can be made for a useful association.

Full Text

Cited Authors

  • James, NM; Smouse, PE; Carroll, BJ; Haines, RF

Published Date

  • 1980

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 208 - 216

PubMed ID

  • 7393431

Pubmed Central ID

  • 7393431

International Standard Serial Number (ISSN)

  • 0302-282X

Digital Object Identifier (DOI)

  • 10.1159/000117754


  • eng

Conference Location

  • Switzerland