Behavioral activation by enkephalins in mice.


Journal Article

Intraventricular injection of long lasting enkephalin analogues (D--Ala2Leu and Met enkephalin-amides) produced a sustained elevation of psychomotor activity in mice. The motor syndromes were characterized by continual stereotyped activity and were reversed by naloxone pretreatment. Naloxone administered to a separate group of mice reduced the initial activation seen after exposure to a novel environment. The present findings suggest one or more endogenous opiates normally facilitates behavioral excitation in mice.

Full Text

Cited Authors

  • Katz, RJ; Carroll, BJ; Baldrighi, G

Published Date

  • April 1, 1978

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 493 - 496

PubMed ID

  • 674255

Pubmed Central ID

  • 674255

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(78)90090-4


  • eng

Conference Location

  • United States