Prolactin response to morphine in depression.


Journal Article

Twenty-two unmedicated inpatients with major depression and 18 healthy volunteers of either sex were given an intravenous injection of 5 mg morphine. Blood samples were drawn immediately before and at intervals for 3 hrs after the injection and assayed for prolactin. Morphine stimulated prolactin secretion. The prolactin response of females was significantly greater than the response of male subjects. There were no significant differences in the prolactin response to morphine between depressed and healthy subjects. The implications of these findings for the hypothesized role of the opioid system in the pathophysiology of depression are discussed.

Full Text

Cited Authors

  • Zis, AP; Haskett, RF; Albala, AA; Carroll, BJ; Lohr, NE

Published Date

  • March 1, 1985

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 287 - 292

PubMed ID

  • 3978163

Pubmed Central ID

  • 3978163

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(85)90058-7


  • eng

Conference Location

  • United States