Effects of dopamine agonists and antagonists in Tourette's disease.


Journal Article

The actions of haloperidol, dextroamphetamine sulfate, levamfetamine succinate, apomorphine, and piribedil were studied in two patients with Giles de la Tourette's disease in an attempt to clarify the catecholamine mechanisms involved in this condition. Both dextroamphetamine and levamfetamine increased the severity of the symptoms; dextroamphetamine was more potent. Haloperidol controlled the symptoms and also antagonized the effect of dextroamphetamine. Apomorphine injections reduced the severity of symptoms, even in the presence of dextroamphetamine. We conclude that dopamine rather than norepinephrine is the principal catecholamine responsible for the symptoms. The effect of apomorphine may be understood through its action on postulated presynaptic inhibitory dopamine receptors, or other presynaptic mechanisms of action.

Full Text

Cited Authors

  • Feinberg, M; Carroll, BJ

Published Date

  • August 1, 1979

Published In

Volume / Issue

  • 36 / 9

Start / End Page

  • 979 - 985

PubMed ID

  • 380492

Pubmed Central ID

  • 380492

International Standard Serial Number (ISSN)

  • 0003-990X

Digital Object Identifier (DOI)

  • 10.1001/archpsyc.1979.01780090065007


  • eng

Conference Location

  • United States