Self-reported diurnal mood changes, early morning awakening and the dexamethasone suppression test in endogenous depression.


Journal Article

Several authors have suggested that Dexamethasone Suppression Test (DST) non-suppression is related to circadian alternations of hypothalamic-pituitary-adrenal function. Two clinical manifestations of altered circadian rhythms in depressed patients are early morning awakening and diurnal variation in mood. To observe whether these clinical symptom patterns were associated with an increased frequency of abnormal DSTs, we examined post-DST plasma cortisol concentrations and matched clinical ratings of early morning awakening and diurnal variation in mood in 49 patients with major depressive disorder, endogenous subtype. We found no significant association between these clinical and laboratory variables.

Full Text

Cited Authors

  • Grunhaus, L; Flegel, P; Carroll, BJ; Greden, JF

Published Date

  • January 1, 1985

Published In

Volume / Issue

  • 8 / 1

Start / End Page

  • 1 - 7

PubMed ID

  • 3156907

Pubmed Central ID

  • 3156907

International Standard Serial Number (ISSN)

  • 0165-0327

Digital Object Identifier (DOI)

  • 10.1016/0165-0327(85)90066-7


  • eng

Conference Location

  • Netherlands