Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease.

Published

Journal Article

The protein melanotransferrin (p97) is associated with the brain lesions of Alzheimer's disease (AD) and is a potential marker of the disorder. We measured serum p97 concentrations in 211 subjects: 71 patients with AD, 56 patients with non-AD-type dementia, and 84 normal control subjects. Serum p97 concentrations were elevated 3- to 4-fold in AD (median 15.00 pg/microl, interquartile range 10.20-17.00 pg/microl) as compared to non AD dementia (2.85 pg/microl, 1.93-7.15 pg/microl) and normal controls (3.20 pg/microl, 2.55-3.95 pg/microl). The mean elevation was significant at 13.54 +/- 3.72 pg/microl, even in the 38 subjects with mild AD (CDR stage 0.5-1). Receiver operating characteristic analyses confirmed an optimal diagnostic threshold of 10.0 pg/microl, which yielded over-all accuracy of 0.882 to 0.915. Serum p97 is a candidate marker of AD, even in the early stage when clinical diagnosis is most uncertain.

Full Text

Cited Authors

  • Kim, DK; Seo, MY; Lim, SW; Kim, S; Kim, JW; Carroll, BJ; Kwon, DY; Kwon, T; Kang, SS

Published Date

  • July 2001

Published In

Volume / Issue

  • 25 / 1

Start / End Page

  • 84 - 90

PubMed ID

  • 11377921

Pubmed Central ID

  • 11377921

International Standard Serial Number (ISSN)

  • 0893-133X

Digital Object Identifier (DOI)

  • 10.1016/S0893-133X(00)00230-X

Language

  • eng

Conference Location

  • England