Intracranial reward after Lilly 110140 (fluoxetine HCl): evidence for an inhibitory role for serotonin.


Journal Article

The 5-hydroxytryptamine (5-HT, serotonin) specific presynaptic reuptake inhibitor Lilly 110140 (fluoxetine hydroxhloride) was injected systemically in rats trained to bar-press for rewarding stimulation to the caudal portion of the medial forebrain bundle. Rates of self stimulation were reduced in proportion to drug dosage, and these reductions were partially reversible by methysergide. These findings are consistent with previous reports suggesting an inhibitory role for 5-HT in self stimulation.

Full Text

Cited Authors

  • Katz, RJ; Carroll, BJ

Published Date

  • January 31, 1977

Published In

Volume / Issue

  • 51 / 2

Start / End Page

  • 189 - 193

PubMed ID

  • 402672

Pubmed Central ID

  • 402672

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/bf00431739


  • eng

Conference Location

  • Germany