Plasma cortisol determination for the dexamethasone suppression test. Comparison of competitive protein-binding and commercial radioimmunoassay methods.


Journal Article

Quality control serum samples and postdexamethasone plasma pools were used to compare 16 commercial cortisol radioimmunoassay kits with the competitive protein-binding assay for plasma glucocorticoids that we used to standardize the dexamethasone suppression test (DST). Thirteen radioimmunoassays gave higher criterion values for the DST than those established using the competitive protein-binding assay. The range of radioimmunoassay criterion values was 4.34 to 8.70 mu mg/dL. Possible explanations are given for these findings, and their importance to the clinical utility of the DST are emphasized. Each laboratory should validate its own criterion cortisol value for depression based on local data, including appropriate control groups.

Full Text

Cited Authors

  • Ritchie, JC; Carroll, BJ; Olton, PR; Shively, V; Feinberg, M

Published Date

  • May 1, 1985

Published In

Volume / Issue

  • 42 / 5

Start / End Page

  • 493 - 497

PubMed ID

  • 3985759

Pubmed Central ID

  • 3985759

International Standard Serial Number (ISSN)

  • 0003-990X

Digital Object Identifier (DOI)

  • 10.1001/archpsyc.1985.01790280075007


  • eng

Conference Location

  • United States