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Bilateral angle closure following use of a weight loss combination agent containing topiramate.

Publication ,  Journal Article
Grewal, DS; Goldstein, DA; Khatana, AK; Tanna, AP
Published in: J Glaucoma
2015

PURPOSE: To report a unique case of topiramate-induced bilateral angle closure following ingestion of a recently introduced weight loss medication containing topiramate, and to describe its management. METHODS: Case report of a 39-year-old, otherwise healthy woman who experienced decreased vision, bilateral acute angle closure, choroidal thickening as measured with enhanced depth optical coherence tomography imaging, bilateral suprachoroidal effusions, and induced myopia 1 week after starting a weight loss medication, Qysmia, composed of phentermine 3.75 mg and topiramate 23 mg. Treatment was initiated with high-dose intravenous methylprednisolone, intravenous mannitol, topical difluprednate ophthalmic emulsion, atropine sulfate, and the fixed combination of brimonidine and timolol. At the 2-week follow-up visit, vision, intraocular pressure, and angle anatomy had returned to normal and there was resolution of choroidal and ciliary body effusions on ultrasound biomicroscopy. CONCLUSIONS: Bilateral acute angle closure may develop after ingestion of weight loss drugs containing topiramate.

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Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

2015

Volume

24

Issue

5

Start / End Page

e132 / e136

Location

United States

Related Subject Headings

  • Weight Loss
  • Topiramate
  • Tonometry, Ocular
  • Tomography, Optical Coherence
  • Timolol
  • Quinoxalines
  • Phentermine
  • Ophthalmology & Optometry
  • Microscopy, Acoustic
  • Mannitol
 

Citation

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Grewal, D. S., Goldstein, D. A., Khatana, A. K., & Tanna, A. P. (2015). Bilateral angle closure following use of a weight loss combination agent containing topiramate. J Glaucoma, 24(5), e132–e136. https://doi.org/10.1097/IJG.0000000000000157
Grewal, Dilraj S., Debra A. Goldstein, Anup K. Khatana, and Angelo P. Tanna. “Bilateral angle closure following use of a weight loss combination agent containing topiramate.J Glaucoma 24, no. 5 (2015): e132–36. https://doi.org/10.1097/IJG.0000000000000157.
Grewal DS, Goldstein DA, Khatana AK, Tanna AP. Bilateral angle closure following use of a weight loss combination agent containing topiramate. J Glaucoma. 2015;24(5):e132–6.
Grewal, Dilraj S., et al. “Bilateral angle closure following use of a weight loss combination agent containing topiramate.J Glaucoma, vol. 24, no. 5, 2015, pp. e132–36. Pubmed, doi:10.1097/IJG.0000000000000157.
Grewal DS, Goldstein DA, Khatana AK, Tanna AP. Bilateral angle closure following use of a weight loss combination agent containing topiramate. J Glaucoma. 2015;24(5):e132–e136.

Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

2015

Volume

24

Issue

5

Start / End Page

e132 / e136

Location

United States

Related Subject Headings

  • Weight Loss
  • Topiramate
  • Tonometry, Ocular
  • Tomography, Optical Coherence
  • Timolol
  • Quinoxalines
  • Phentermine
  • Ophthalmology & Optometry
  • Microscopy, Acoustic
  • Mannitol