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Impact of obesity on health-related quality of life in schizophrenia and bipolar disorder.

Publication ,  Journal Article
Kolotkin, RL; Corey-Lisle, PK; Crosby, RD; Swanson, JM; Tuomari, AV; L'italien, GJ; Mitchell, JE
Published in: Obesity (Silver Spring)
April 2008

OBJECTIVE: Studies have reported that up to 60% of individuals with schizophrenia and 68% of those with bipolar disorder are overweight/obese. This paper explores the health-related quality of life (HRQOL) of individuals with schizophrenia or bipolar disorder as a function of obesity status. METHODS AND PROCEDURES: Two hundred and eleven participants were recruited from four psychiatric programs (outpatient, day treatment, case management, and psychosocial rehabilitation). HRQOL was assessed using both a general measure (Medical Outcomes Study Short-Form-36 (SF-36)) and a weight-related measure (Impact of Weight on Quality of Life-Lite (IWQOL-Lite)). To interpret HRQOL scores obtained by the obese group, we compared scores to those obtained by reference groups from the weight-loss literature. RESULTS: Sixty-three percent of participants with schizophrenia and 68% of those with bipolar disorder were obese. Obese participants were more likely to be women, on mood stabilizers, taking a greater number of psychiatric medications, and to have poorer weight-related and general HRQOL. Weight-related HRQOL in the obese psychiatric sample was more impaired than in outpatient and day treatment samples seeking weight loss but less impaired than in gastric-bypass patients. Several of the physical domains of general HRQOL were more impaired for the obese psychiatric sample than for the outpatient weight-loss sample. However, physical functioning was less impaired for the obese psychiatric sample than for gastric-bypass patients. DISCUSSION: The presence of obesity among individuals with schizophrenia or bipolar disorder is associated with decreased HRQOL. These results have implications for prevention and management of weight gain in individuals with schizophrenia or bipolar disorder.

Duke Scholars

Published In

Obesity (Silver Spring)

DOI

ISSN

1930-7381

Publication Date

April 2008

Volume

16

Issue

4

Start / End Page

749 / 754

Location

United States

Related Subject Headings

  • Weight Loss
  • Severity of Illness Index
  • Schizophrenic Psychology
  • Schizophrenia
  • Quality of Life
  • Obesity
  • Middle Aged
  • Male
  • Humans
  • Health Status
 

Citation

APA
Chicago
ICMJE
MLA
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Kolotkin, R. L., Corey-Lisle, P. K., Crosby, R. D., Swanson, J. M., Tuomari, A. V., L’italien, G. J., & Mitchell, J. E. (2008). Impact of obesity on health-related quality of life in schizophrenia and bipolar disorder. Obesity (Silver Spring), 16(4), 749–754. https://doi.org/10.1038/oby.2007.133
Kolotkin, Ronette L., Patricia K. Corey-Lisle, Ross D. Crosby, Jodi M. Swanson, Anne V. Tuomari, Gilbert J. L’italien, and James E. Mitchell. “Impact of obesity on health-related quality of life in schizophrenia and bipolar disorder.Obesity (Silver Spring) 16, no. 4 (April 2008): 749–54. https://doi.org/10.1038/oby.2007.133.
Kolotkin RL, Corey-Lisle PK, Crosby RD, Swanson JM, Tuomari AV, L’italien GJ, et al. Impact of obesity on health-related quality of life in schizophrenia and bipolar disorder. Obesity (Silver Spring). 2008 Apr;16(4):749–54.
Kolotkin, Ronette L., et al. “Impact of obesity on health-related quality of life in schizophrenia and bipolar disorder.Obesity (Silver Spring), vol. 16, no. 4, Apr. 2008, pp. 749–54. Pubmed, doi:10.1038/oby.2007.133.
Kolotkin RL, Corey-Lisle PK, Crosby RD, Swanson JM, Tuomari AV, L’italien GJ, Mitchell JE. Impact of obesity on health-related quality of life in schizophrenia and bipolar disorder. Obesity (Silver Spring). 2008 Apr;16(4):749–754.
Journal cover image

Published In

Obesity (Silver Spring)

DOI

ISSN

1930-7381

Publication Date

April 2008

Volume

16

Issue

4

Start / End Page

749 / 754

Location

United States

Related Subject Headings

  • Weight Loss
  • Severity of Illness Index
  • Schizophrenic Psychology
  • Schizophrenia
  • Quality of Life
  • Obesity
  • Middle Aged
  • Male
  • Humans
  • Health Status