An acoustofluidic sputum liquefier.


Journal Article

We demonstrate the first microfluidic-based on-chip liquefaction device for human sputum samples. Our device is based on an acoustofluidic micromixer using oscillating sharp edges. This acoustofluidic sputum liquefier can effectively and uniformly liquefy sputum samples at a throughput of 30 μL min(-1). Cell viability and integrity are maintained during the sputum liquefaction process. Our acoustofluidic sputum liquefier can be conveniently integrated with other microfluidic units to enable automated on-chip sputum processing and analysis.

Full Text

Cited Authors

  • Huang, P-H; Ren, L; Nama, N; Li, S; Li, P; Yao, X; Cuento, RA; Wei, C-H; Chen, Y; Xie, Y; Nawaz, AA; Alevy, YG; Holtzman, MJ; McCoy, JP; Levine, SJ; Huang, TJ

Published Date

  • August 2015

Published In

Volume / Issue

  • 15 / 15

Start / End Page

  • 3125 - 3131

PubMed ID

  • 26082346

Pubmed Central ID

  • 26082346

Electronic International Standard Serial Number (EISSN)

  • 1473-0189

International Standard Serial Number (ISSN)

  • 1473-0197

Digital Object Identifier (DOI)

  • 10.1039/c5lc00539f


  • eng