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Enteroviruses in the early 21st century: new manifestations and challenges.

Publication ,  Journal Article
Lugo, D; Krogstad, P
Published in: Curr Opin Pediatr
February 2016

PURPOSE OF REVIEW: Enteroviruses cause a wide variety of diseases with neurologic, respiratory, skin, and gastrointestinal findings. The purpose of this review is to clarify changes in the classification of enteroviruses, provide information about recent disease outbreaks, and to summarize progress toward the treatment and prevention of these infections. RECENT FINDINGS: Enteroviruses are now classified into four distinct species. New variants of coxsackievirus B1, enterovirus-A71, and enterovirus-D68 (EV-D68) have emerged as causes of recent outbreaks in the United States and other countries, including more severe disease manifestations than previously described. EV-D68 now commonly circulates in the United States, and has been linked to severe respiratory disease and associated with acute flaccid myelitis (AFM). Overcoming enormous political and logistical challenges, fewer than 100 cases of polio have been reported in 2015, and the initiation of 'endgame' strategies appears imminent. Unfortunately, treatment for enterovirus infections remains supportive, although the recently completed pleconaril trial in newborns suggests that antiviral therapy may reduce mortality in neonatal disease. SUMMARY: Clinicians should be aware of the respiratory and neurological manifestations associated with EV-D68 and the potential for severe disease seen with other recently described enterovirus variants. Healthcare professionals should recognize the utility of rapid diagnostic methods and progress toward prevention and treatment of enterovirus infections.

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Published In

Curr Opin Pediatr

DOI

EISSN

1531-698X

Publication Date

February 2016

Volume

28

Issue

1

Start / End Page

107 / 113

Location

United States

Related Subject Headings

  • Viral Vaccines
  • Poliomyelitis
  • Pediatrics
  • Myocarditis
  • Myelitis
  • Infant, Newborn
  • Humans
  • Hand, Foot and Mouth Disease
  • Enterovirus Infections
  • Enterovirus B, Human
 

Citation

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Lugo, D., & Krogstad, P. (2016). Enteroviruses in the early 21st century: new manifestations and challenges. Curr Opin Pediatr, 28(1), 107–113. https://doi.org/10.1097/MOP.0000000000000303
Lugo, Debra, and Paul Krogstad. “Enteroviruses in the early 21st century: new manifestations and challenges.Curr Opin Pediatr 28, no. 1 (February 2016): 107–13. https://doi.org/10.1097/MOP.0000000000000303.
Lugo D, Krogstad P. Enteroviruses in the early 21st century: new manifestations and challenges. Curr Opin Pediatr. 2016 Feb;28(1):107–13.
Lugo, Debra, and Paul Krogstad. “Enteroviruses in the early 21st century: new manifestations and challenges.Curr Opin Pediatr, vol. 28, no. 1, Feb. 2016, pp. 107–13. Pubmed, doi:10.1097/MOP.0000000000000303.
Lugo D, Krogstad P. Enteroviruses in the early 21st century: new manifestations and challenges. Curr Opin Pediatr. 2016 Feb;28(1):107–113.

Published In

Curr Opin Pediatr

DOI

EISSN

1531-698X

Publication Date

February 2016

Volume

28

Issue

1

Start / End Page

107 / 113

Location

United States

Related Subject Headings

  • Viral Vaccines
  • Poliomyelitis
  • Pediatrics
  • Myocarditis
  • Myelitis
  • Infant, Newborn
  • Humans
  • Hand, Foot and Mouth Disease
  • Enterovirus Infections
  • Enterovirus B, Human