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Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis: A Prospective Crossover Study.

Publication ,  Journal Article
Kothari, D; Ketwaroo, G; Sawhney, MS; Freedman, SD; Sheth, SG
Published in: Pancreas
July 2017

OBJECTIVE: We aimed to determine the feasibility and accuracy of a combined endoscopic ultrasonography (EUS) with a shortened pancreatic function testing (sEUS) for structural and functional assessment using a single instrument in patients with suspected chronic pancreatitis (CP). METHODS: We completed a prospective crossover study, enrolling patients with suspected CP. Patients who underwent both traditional 1-hour secretin pancreatic function test (sPFT) and sEUS were included in the analysis. We compared study results for test concordance and for correlation of peak bicarbonate concentrations. RESULTS: Eleven (64.7%) of 17 patients had concordant sPFT and sEUS findings when the cutoff for peak bicarbonate was 80 mEq/L. Six patients had discordant findings with a negative sPFT and positive sEUS. This poor concordance suggests that sEUS is an unreliable functional test. Lowering the sEUS cutoff to 70 mEq/L resulted in improved concordance (64.7% vs 70.6%). Finally, there was no significant correlation between peak bicarbonate concentrations (r = 0.47; 95% confidence interval, -0.02 to 0.79) in these 2 functional tests. CONCLUSIONS: We demonstrate poor concordance between sPFT and sEUS suggesting that a combined shortened functional and structural test using a single instrument may not be a feasible test for diagnosis of suspected CP when a cutoff of 80 mEq/L is used.

Duke Scholars

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Published In

Pancreas

DOI

EISSN

1536-4828

Publication Date

July 2017

Volume

46

Issue

6

Start / End Page

770 / 775

Location

United States

Related Subject Headings

  • Workflow
  • Time Factors
  • Secretin
  • Reproducibility of Results
  • Prospective Studies
  • Prognosis
  • Predictive Value of Tests
  • Pancreatitis, Chronic
  • Pancreatic Juice
  • Pancreatic Function Tests
 

Citation

APA
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ICMJE
MLA
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Kothari, D., Ketwaroo, G., Sawhney, M. S., Freedman, S. D., & Sheth, S. G. (2017). Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis: A Prospective Crossover Study. Pancreas, 46(6), 770–775. https://doi.org/10.1097/MPA.0000000000000829
Kothari, Darshan, Gyanprakash Ketwaroo, Mandeep S. Sawhney, Steven D. Freedman, and Sunil G. Sheth. “Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis: A Prospective Crossover Study.Pancreas 46, no. 6 (July 2017): 770–75. https://doi.org/10.1097/MPA.0000000000000829.

Published In

Pancreas

DOI

EISSN

1536-4828

Publication Date

July 2017

Volume

46

Issue

6

Start / End Page

770 / 775

Location

United States

Related Subject Headings

  • Workflow
  • Time Factors
  • Secretin
  • Reproducibility of Results
  • Prospective Studies
  • Prognosis
  • Predictive Value of Tests
  • Pancreatitis, Chronic
  • Pancreatic Juice
  • Pancreatic Function Tests