Intravitreal Adalimumab for the Control of Breakthrough Intraocular Inflammation.


Journal Article

PURPOSE: Investigate the efficacy of intravitreal adalimumab in breakthrough panuveitis in patients on systemic adalimumab for more than 3 months. METHODS: Retrospective study of patients on systemic adalimumab with breakthrough panuveitis requiring intravitreal adalimumab therapy. RESULTS: Seven eyes of four patients with Adamantiades-Behçet disease panuveitis were included and all were maintained on systemic adalimumab for 7.3 months (range 3-11) with inflammation controlled for 4.1 months (range 2-10) before breakthrough uveitis. The total number of attacks was 13 over 24.5 months (range 12-30). Resolution of attack was defined as return to baseline visual acuity with resolution of inflammatory markers. Three attacks resolved after only one injection and 10 attacks required an average of 2.4 injections (range 2-3). No systemic or ocular complications were noted. CONCLUSIONS: Intravitreal adalimumab warrants further investigation as a potentially effective, practical and safe adjunctive therapy for the control of breakthrough inflammation in select patients maintained on systemic adalimumab.

Full Text

Cited Authors

  • Kheir, WJ; Mehanna, C-J; Abdul Fattah, M; Al Ghadban, S; El Sabban, M; Mansour, AM; Hamam, RN

Published Date

  • 2018

Published In

Volume / Issue

  • 26 / 8

Start / End Page

  • 1206 - 1211

PubMed ID

  • 28910560

Pubmed Central ID

  • 28910560

Electronic International Standard Serial Number (EISSN)

  • 1744-5078

Digital Object Identifier (DOI)

  • 10.1080/09273948.2017.1335756


  • eng

Conference Location

  • England